RALGAPA2 - Ral GTPase activating protein catalytic subunit alpha 2 Gene

中文名称：Ral GTPase 激活蛋白催化亚基 alpha 2

种属: Homo sapiens

同用名: p220; AS250; C20orf74; dJ1049G11; bA287B20.1; dJ1049G11.4

基因 ID: 57186 | 基因类型: protein coding

关于 RALGAPA2

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:20,389,530-20,712,644 (from NCBI)

This gene has 5 transcripts (splice variants), 221 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 9.1), placenta (RPKM 6.4) and 25 other tissues.

功能概要

预测可启用 GTPase 激活剂活性和蛋白质异二聚化活性。预测参与 GTPase 活性的激活。预计作用于 Ral 蛋白信号转导的上游或内部；外囊定位的调节；和蛋白质定位的调节。位于胞质溶胶和质膜中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTPase activator activity and protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RALGAPA2 基因产物(1)

mRNA	Protein	Name
NM_020343.4	NP_065076.2	ral GTPase-activating protein subunit alpha-2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16490346	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RALGAPA2 蛋白结构

Rap_GAP

0
300
600
900
1200
1500
1873 a.a.

蛋白主名

其他名称

ral GTPase-activating protein subunit alpha-2

250 kDa substrate of Akt

RALGAPA2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RALGAPA2	Q2PPJ7	DDI1	Homo sapiens	Q8WTU0	Validated Y2H	32296183
种属内	RALGAPA2	Q2PPJ7	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	32296183
种属内	RALGAPA2	Q2PPJ7	DDI1	Homo sapiens	Q8WTU0	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Congenital Myasthenic Syndrome 7

Cms7	Congenital Myasthenic Syndrome 7 Presynaptic
Myasthenic Syndrome, Congenital, Type 7, Presynaptic

Ohdo Syndrome, Sbbys Variant

Say-Barber-Biesecker-Young-Simpson Syndrome	SBBYSS
Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Sbbys Type
Yss	Sbbys Variant Of Ohdo Syndrome
Blepharophimosis - Intellectual Disability Syndrome, Sbbys Type	Young Simpson Syndrome
Sbbyss Syndrome	Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant
Blepharophimosis And Mental Retardation Syndrome, Say-Barber/Biesecker/Young-Simpson Type	Blepharophimosis-Intellectual Deficit Syndrome, Say-Barber/Biesecker/Young-Simpson Type
Bmrs Sbbys	Ohdo Syndrome, Say-Barber-Biesecker Variant
Say-Barber-Biesecker-Young-Simpson Variant Of Ohdo Syndrome	Hypothyroidism-Dysmorphism-Postaxial Polydactyly-Intellectual Disability Syndrome
Say-Barber-Biesecker Variant Of Ohdo Syndrome

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Sbbys Syndrome
Say Barber Biesecker Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Bmrs, Ohdo Type	Blepharophimosis Syndrome, Ohdo Type
Ohdo-Madokoro-Sonoda Syndrome	Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type
Blepharophimosis - Intellectual Disability Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11631	RALGAPA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	RALGAPA2	VGNC	VGNC:81166
Canis familiaris	RALGAPA2	VGNC	VGNC:45333
Bos taurus	RALGAPA2	VGNC	VGNC:33702
Macaca mulatta	RALGAPA2	VGNC	VGNC:76488
Mus musculus	RALGAPA2	MGD	MGI:3036245
Rattus norvegicus	RALGAPA2	RGD	RGD:1308023

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RALGAPA2 - Ral GTPase activating protein catalytic subunit alpha 2 Gene

关于 RALGAPA2

功能概要

RALGAPA2 基因产物(1)

RALGAPA2 蛋白结构

RALGAPA2 蛋白互作信息

关联疾病

直系同源

热门区域

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RALGAPA2 - Ral GTPase activating protein catalytic subunit alpha 2 Gene

关于 RALGAPA2

功能概要

RALGAPA2 基因产物(1)

RALGAPA2 蛋白结构

RALGAPA2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z