PTPRE - protein tyrosine phosphatase receptor type E Gene

中文名称：E 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: PTPE; HPTPE; R-PTP-EPSILON

关于 PTPRE

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。已经报道了该基因的几种选择性剪接的转录物变体，其中至少有两种编码受体型 PTP，该 PTP 具有一个短的细胞外结构域、一个跨膜区域和两个串联的胞质内催化结构域；另一个编码包含不同亲水性 N 末端的 PTP，因此代表该 PTP 的非受体型亚型。对小鼠中相似基因的研究表明，该 PTP 在 Ras 相关信号转导通路、细胞因子诱导的 SATA 信号转导以及电压门控 K+ 通道的激活中具有调节作用。[RefSeq 提供，2015 年 10 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in Ras related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]