2. Gene
  3. Cacnb4 - calcium voltage-gated channel auxiliary subunit beta 4 Gene

Cacnb4 - calcium voltage-gated channel auxiliary subunit beta 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: CAB4

基因 ID: 58942 | 基因类型: protein coding

关于 Cacnb4

功能概要

Enables protein kinase binding activity and voltage-gated Calcium Channel activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of protein localization to nucleolus; and positive regulation of voltage-gated Calcium Channel activity. Located in cytoplasm; nuclear speck; and nucleolus. Is active in presynapse. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and idiopathic generalized epilepsy 9. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]

Cacnb4 基因产物(2)

mRNA Protein Name
NM_001105733.2 NP_001099203.1 voltage-dependent L-type calcium channel subunit beta-4 isoform 2
NM_001399143.1 NP_001386072.1 voltage-dependent L-type calcium channel subunit beta-4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11988102 RGD
enables protein kinase binding IDA
IDA: 通过直接分析推断
18205403 RGD
enables voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
12821675 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium ion transport IMP
IMP: 通过突变表型推断
12821675 RGD
involved in negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
28587927 RGD
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
28587927 RGD
involved in positive regulation of protein localization to nucleolus IDA
IDA: 通过直接分析推断
28587927 RGD
involved in positive regulation of voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
12821675 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear speck IDA
IDA: 通过直接分析推断
28587927 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
10931840 RGD
is active in presynapse IMP
IMP: 通过突变表型推断
10931840 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

voltage-dependent L-type calcium channel subunit beta-4

calcium channel beta 4 subunit

calcium channel voltage-dependent subunit beta 4

calcium channel, voltage-dependent, beta 4 subunit

Cacnb4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Cacnb4 D4A055 Thra Mus musculus P63058
Y2H
22892567
种属间
Cacnb4 D4A055 Ppp2r5d Mus musculus Q91V89
Y2H
22892567
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01808 CACNB4 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cacnb4 NCBI NCBI:785
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