2. Gene
  3. Thra - thyroid hormone receptor alpha Gene

Thra - thyroid hormone receptor alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Rvr; Erba; Nr1a1; Thra1; Thra2; T3R[a]; T3Ralpha; c-erbA-1; c-erbAalpha; c-erbA-alpha; 6430529J03Rik

基因 ID: 21833 | 基因类型: protein coding

关于 Thra

功能概要

The protein encoded by this gene is one of several nuclear hormone receptors that bind thyroid Hormones such as triiodothyronine and thyroxine with high affinity. The encoded protein is a transcription factor that can activate or repress transcription. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]

Thra 基因产物(2)

mRNA Protein Name
NM_001313983.1 NP_001300912.1 thyroid hormone receptor alpha isoform 1
NM_178060.4 NP_835161.1 thyroid hormone receptor alpha isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables DNA binding IDA
IDA: 通过直接分析推断
16322094 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
17952069 MGI
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
15322135 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11641275 MGI
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
15340084 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
19001373 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
9927422 MGI
acts upstream of or within cartilage condensation IMP
IMP: 通过突变表型推断
9250685 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: 通过突变表型推断
18203951 MGI
acts upstream of or within female courtship behavior IMP
IMP: 通过突变表型推断
10769387 MGI
acts upstream of or within learning or memory IMP
IMP: 通过突变表型推断
17129617 MGI
involved in mRNA transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8910441 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11641275 MGI
acts upstream of or within ossification IMP
IMP: 通过突变表型推断
9250685 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
21652727 MGI
acts upstream of or within positive regulation of female receptivity IMP
IMP: 通过突变表型推断
10769387 MGI
involved in positive regulation of thyroid hormone receptor signaling pathway IDA
IDA: 通过直接分析推断
8910441 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15340084 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8910441 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19001373 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: 通过突变表型推断
9430637 MGI
acts upstream of or within regulation of lipid catabolic process IMP
IMP: 通过突变表型推断
12869545 MGI
acts upstream of or within regulation of myeloid cell apoptotic process IMP
IMP: 通过突变表型推断
18203951 MGI
acts upstream of or within regulation of thyroid hormone receptor signaling pathway IMP
IMP: 通过突变表型推断
12869545 MGI
acts upstream of or within response to cold IMP
IMP: 通过突变表型推断
12869545 MGI
acts upstream of or within thyroid gland development IGI
IGI: 通过遗传相互作用推断
11773436 MGI
acts upstream of or within type I pneumocyte differentiation IGI
IGI: 通过遗传相互作用推断
22001906 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
8910441 MGI
located in nucleus IDA
IDA: 通过直接分析推断
17952069 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

thyroid hormone receptor alpha

TR alpha 1

TR alpha 2

nuclear receptor subfamily 1 group A member 1

Thra 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Thra P63058 Cacnb4 Rattus norvegicus D4A055
Anti Tag CoIP
22892567
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14499 THRA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17595 Thra Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24055 Thra Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Thra NCBI NCBI:7067
Rattus norvegicus Thra NCBI NCBI:81812
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