2. Gene
  3. Unc13a - unc-13 homolog A Gene

Unc13a - unc-13 homolog A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Unc13h1; Munc13-1

基因 ID: 64829 | 基因类型: protein coding

关于 Unc13a

功能概要

Enables several functions, including Calmodulin binding activity; spectrin binding activity; and syntaxin-1 binding activity. Involved in long-term synaptic potentiation; regulated exocytosis; and regulation of synaptic vesicle priming. Located in several cellular components, including Golgi-associated vesicle; presynaptic active zone cytoplasmic component; and presynaptic membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human UNC13A (unc-13 homolog A). [provided by Alliance of Genome Resources, Apr 2022]

Unc13a 基因产物(1)

mRNA Protein Name
NM_022861.2 NP_074052.2 protein unc-13 homolog A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SNARE binding IDA
IDA: 通过直接分析推断
18201107 RGD
enables calmodulin binding IDA
IDA: 通过直接分析推断
19492809 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16732694 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8999968 RGD
enables protein domain specific binding IDA
IDA: 通过直接分析推断
16732694 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
16732694 RGD
enables spectrin binding IPI
IPI: 通过物理相互作用推断
9704016 RGD
enables syntaxin binding IDA
IDA: 通过直接分析推断
9895278 RGD
enables syntaxin-1 binding IDA
IDA: 通过直接分析推断
9895278 RGD
enables syntaxin-1 binding IPI
IPI: 通过物理相互作用推断
8999968 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dense core granule priming IGI
IGI: 通过遗传相互作用推断
26575293 RGD
involved in long-term synaptic potentiation IMP
IMP: 通过突变表型推断
21849565 RGD
involved in neurotransmitter secretion IDA
IDA: 通过直接分析推断
7559667 RGD
involved in regulation of synaptic vesicle priming IDA
IDA: 通过直接分析推断
21689256 RGD
involved in synaptic vesicle priming IDA
IDA: 通过直接分析推断
21499244 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi-associated vesicle IDA
IDA: 通过直接分析推断
22875941 RGD
located in excitatory synapse IDA
IDA: 通过直接分析推断
19730411 RGD
located in presynaptic active zone IDA
IDA: 通过直接分析推断
22875941 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
8999968 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
16732694 RGD
located in synaptic membrane IDA
IDA: 通过直接分析推断
9895278 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein unc-13 homolog A

Unc13a 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Unc13a Q62768 Stxbp1 Rattus norvegicus P61765
NMR
22000513
种属内
Unc13a Q62768 Rims2 Rattus norvegicus Q9JIS1
X-Ray Diffraction
16732694
种属内
Unc13a Q62768 Unc13a Rattus norvegicus Q62768
X-Ray Diffraction
16732694
种属内
Unc13a Q62768 Unc13a Rattus norvegicus Q62768
Solution Sedimentation
16732694
种属内
Unc13a Q62768 Rims2 Rattus norvegicus Q9JIS1
NMR
16732694
种属内
Unc13a Q62768 Rims2 Rattus norvegicus Q9JIS1
GMS
16732694
种属内
Unc13a Q62768 Unc13a Rattus norvegicus Q62768
GMS
16732694
种属内
Unc13a Q62768 Stx1a Rattus norvegicus P32851
NMR
22000513
种属内
Unc13a Q62768 Unc13a Rattus norvegicus Q62768
NMR
16732694
种属内
Unc13a Q62768 Rims2 Rattus norvegicus Q9JIS1
ITC
16732694
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15464 UNC13A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21216 Unc13a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27732 Unc13a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Unc13a NCBI NCBI:23025
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