2. Gene
  3. Dhodh - dihydroorotate dehydrogenase (quinone) Gene

Dhodh - dihydroorotate dehydrogenase (quinone) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：二氢乳清酸脱氢酶 (醌)

种属: Rattus norvegicus

基因 ID: 65156 | 基因类型: protein coding

关于 Dhodh

Primary_assembly 19: 37,558,177-37,591,654 reverse strand.mRatBN7.2:CM026992.1

This gene has 5 transcripts (splice variants), 173 orthologues, 1 paralogue and is associated with 12 phenotypes. Biased expression in Adrenal (RPKM 46.5), Thymus (RPKM 4.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 FMN 绑定活动；二氢乳清酸脱氢酶活性；和泛醌结合活性。参与多个过程，包括“从头”嘧啶核碱基生物合成过程；哺乳；和对 L-精氨酸的反应。位于线粒体内膜和神经细胞体。该基因的人类直系同源物与轴后性肢端骨发育不全有关。与人 DHODH（二氢乳清酸脱氢酶（醌））同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables FMN binding activity; Dihydroorotate Dehydrogenase activity; and ubiquinone binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; lactation; and response to L-arginine. Located in mitochondrial inner membrane and neuronal cell body. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (Dihydroorotate Dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Apr 2022]

Dhodh 基因产物(1)

mRNA Protein Name
NM_001008553.2 NP_001008553.1 dihydroorotate dehydrogenase (quinone), mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FMN binding IDA
IDA: 通过直接分析推断
9693067 RGD
enables dihydroorotate dehydrogenase activity IDA
IDA: 通过直接分析推断
1313236 RGD
enables quinone binding IPI
IPI: 通过物理相互作用推断
15044733 RGD
enables ubiquinone binding IDA
IDA: 通过直接分析推断
9179295 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 'de novo' pyrimidine nucleobase biosynthetic process IDA
IDA: 通过直接分析推断
1476792 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
1476792 RGD
involved in lactation IEP
IEP: 通过表达模式推断
1476792 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
15182735 RGD
involved in regulation of mitochondrial fission IMP
IMP: 通过突变表型推断
16120318 RGD
involved in response to L-arginine IEP
IEP: 通过表达模式推断
6167833 RGD
involved in response to caffeine IEP
IEP: 通过表达模式推断
6149265 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
9879809 RGD
involved in response to starvation IEP
IEP: 通过表达模式推断
6331524 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
9123312 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
10727948 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
20544541 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Dhodh 蛋白结构

DHOD_2_like

DHOD_2_like: cd04738 (42 - 372)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
蛋白主名 其他名称

dihydroorotate dehydrogenase (quinone), mitochondrial

DHOdehase

dihydroorotate dehydrogenase, mitochondrial

dihydroorotate oxidase

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0083 Leflunomide Inhibitor 99.82% 是
HY-N0157 Orotic acid Chemical 99.98% 否
HY-110159 (E/Z)-Teriflunomide Inhibitor 99.87% 是
HY-N0157A Orotic acid zinc Chemical 99.84% 否
HY-N0157R Orotic acid (Standard) Chemical 99.51% 否
Clinical Phase
生物活性分子 (8)
目录号 产品名 作用方式
纯度 Phase
HY-104029 Olorofim Inhibitor 99.57% Phase 3
HY-108325 Brequinar Inhibitor 99.89% Phase 2
HY-14908 Vidofludimus 99.14% Phase 2
HY-129239 Farudodstat 99.68% Phase 2
HY-175352 Nurr1 Agonist 14 / Phase 2
HY-112645 BAY-2402234 Inhibitor 99.90% Phase 1
HY-137463 AG-636 Inhibitor 98.25% Phase 1
HY-152851 Izumerogant Inhibitor 99.95% Phase 1
Pre-clinical Phase
生物活性分子 (64)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W015495 L-Dihydroorotic acid Substrate 99.94% 否
HY-124593 PTC299 Inhibitor 99.89% 否
HY-N6961 Lapachol Inhibitor 99.49% 否
HY-15510 Tenovin-6 98.00% 否
HY-139189 DHODH-IN-16 Inhibitor 99.88% 否
HY-100688 ML390 Inhibitor 99.72% 否
HY-13423 Tenovin-1 99.88% 否
HY-128068 DHODH-IN-17 Inhibitor 99.91% 否
HY-135282 DHODH-IN-1 Inhibitor 98.65% 否
HY-15510B Tenovin-6 Hydrochloride 98.88% 否
HY-101813 Laflunimus Inhibitor 99.70% 否
HY-N0157S1 Orotic acid-13C,15N2 monohydrate 99.93% 否
HY-153112 DHODH-IN-23 Inhibitor 98.75% 否
HY-132170 DSM502 Inhibitor 99.74% 否
HY-132171A DSM705 hydrochloride Inhibitor 99.56% 否
HY-132174 CHIKV-IN-2 Inhibitor 99.21% 否
HY-128787 hDHODH-IN-4 Inhibitor 99.73% 否
HY-135664 hDHODH-IN-5 Inhibitor 98.55% 否
HY-135675 DHODH-IN-11 Inhibitor 99.69% 否
HY-135678 DHODH-IN-14 Inhibitor 99.81% 否
HY-N3097 Pellitorine 99.84% 否
HY-N7961 (E/Z)-Ginkgolic acid C17:2 Inhibitor 99.37% 否
HY-RS03734 DHODH Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-132171 DSM705 Inhibitor / 否
HY-14908A Vidofludimus hemicalcium / 否
HY-135562 Ascofuranone Inhibitor / 否
HY-135618 DHODH-IN-3 Inhibitor / 否
HY-135619 DHODH-IN-4 Inhibitor / 否
HY-135666 DHODH-IN-8 Inhibitor / 否
HY-135667 hDHODH-IN-7 Inhibitor / 否
HY-135676 DHODH-IN-12 Inhibitor / 否
HY-135677 DHODH-IN-13 Inhibitor / 否
HY-135679 DHODH-IN-15 Inhibitor / 否
HY-139825 Indoluidin E Inhibitor / 否
HY-139889 DHODH-IN-18 Inhibitor / 否
HY-142834 RORγt/DHODH-IN-2 Inhibitor / 否
HY-142843 RORγt/DHODH-IN-1 Inhibitor / 否
HY-142847 RORγt/DHODH-IN-3 Inhibitor / 否
HY-144169 DHODH-IN-19 Inhibitor / 否
HY-144371 DHODH-IN-20 Inhibitor / 否
HY-146317 P1788 Inhibitor / 否
HY-148395 UCK2 Inhibitor-2 Inhibitor / 否
HY-148396 UCK2 Inhibitor-3 / 否
HY-149030 DHODH-IN-21 Inhibitor / 否
HY-149031 DHODH-IN-22 Inhibitor / 否
HY-149877 hDHODH-IN-12 Inhibitor / 否
HY-158023 DHODH-IN-26 / 否
HY-163158 DHODH-IN-24 Inhibitor / 否
HY-163328 DHODH-IN-25 Inhibitor / 否
HY-174816 DHODH-IN-28 Inhibitor / 否
HY-175259 DHODH-IN-29 Inhibitor / 否
HY-176728 DHODH-IN-27 Inhibitor / 否
HY-178156 DHODH-IN-31 Inhibitor / 否
HY-B0083S Leflunomide-d4 Inhibitor / 否
HY-RS03735 Dhodh Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03736 Dhodh Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-108325S Brequinar-d3 Inhibitor / 否
HY-120462 Genz-669178 Inhibitor / 否
HY-129253 GSK984 Control / 否
HY-169220S RORγ/DHODH-IN-1 Inhibitor / 否
HY-169222S RORγ/DHODH-IN-2 Inhibitor / 否
HY-175423 DHODH-IN-30 Inhibitor / 否
HY-B0083S1 Leflunomide-13C6 Inhibitor / 否
HY-120924 BRD9185 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dhodh NCBI NCBI:1723
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z