2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  4. DHODH-IN-14

DHODH-IN-14 (Compound 7l) 是一种 A771726 的 hydroxyfurazan 类似物。DHODH-IN-14 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂，对大鼠肝脏 DHODH 的 IC50 为 0.49 μM。DHODH-IN-14 可用于类风湿关节炎。

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DHODH-IN-14 Chemical Structure

DHODH-IN-14 Chemical Structure

CAS No. : 1364791-93-4

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规格 价格 是否有货 数量
1 mg ￥2207
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DHODH-IN-14 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for rat liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis[1].

IC50 & Target

IC50: 0.49 μM (Rat liver DHODH)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Jurkat IC50
59.7 μM
Compound: 2
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method
[PMID: 28235702]
体外研究
(In Vitro)

DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726, in which the biphenyl scaffold with fluoro substituents. Moving to derivatives DHODH-IN-14, no major differences were observed among the poses obtained on 1UUO and 1D3G; in both cases DHODH-IN-14 is found to bind in a BQN-like fashion, namely with the deprotonated hydroxyfurazan moiety facing Arg136, thus effectively mimicking the carboxyl group of BQN and related compounds. While on 1D3G and 1UUO the hydroxyfurazan is in no case found to interact with Tyr356 in a Leflunomide-like fashion, a significant fraction of such poses is found when 2BXV is used as the docking target[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DHODH-IN-14 相关抗体:
分子量

353.23

Formula

C15H7F4N3O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 125 mg/mL (353.88 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8310 mL 14.1551 mL 28.3102 mL
5 mM 0.5662 mL 2.8310 mL 5.6620 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

DHODH-IN-14 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8310 mL 14.1551 mL 28.3102 mL 70.7754 mL
5 mM 0.5662 mL 2.8310 mL 5.6620 mL 14.1551 mL
10 mM 0.2831 mL 1.4155 mL 2.8310 mL 7.0775 mL
15 mM 0.1887 mL 0.9437 mL 1.8873 mL 4.7184 mL
20 mM 0.1416 mL 0.7078 mL 1.4155 mL 3.5388 mL
25 mM 0.1132 mL 0.5662 mL 1.1324 mL 2.8310 mL
30 mM 0.0944 mL 0.4718 mL 0.9437 mL 2.3592 mL
40 mM 0.0708 mL 0.3539 mL 0.7078 mL 1.7694 mL
50 mM 0.0566 mL 0.2831 mL 0.5662 mL 1.4155 mL
60 mM 0.0472 mL 0.2359 mL 0.4718 mL 1.1796 mL
80 mM 0.0354 mL 0.1769 mL 0.3539 mL 0.8847 mL
100 mM 0.0283 mL 0.1416 mL 0.2831 mL 0.7078 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-141364791-93-4Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHhydroxyfurazanLeflunomideA771726BQNratantiinflammatoryrheumatoidarthritisInhibitorinhibitorinhibit

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