1. Metabolic Enzyme/Protease Immunology/Inflammation
  2. Dihydroorotate Dehydrogenase Interleukin Related FXR
  3. Vidofludimus hemicalcium

Vidofludimus hemicalcium  (Synonyms: 4sc-101 hemicalcium; SC12267 hemicalcium)

目录号: HY-14908A
产品使用指南

Vidofludimus (4sc-101; SC12267) hemicalcium 是一种口服有效的二氢乳清酸脱氢酶 (DHODH) 的抑制剂,也是法尼醇 X 受体 (FXR) 调节剂。Vidofludimus hemicalcium 作为一种免疫调节剂,可用于研究自身免疫性疾病,如炎症性肠病 (IBD)。Vidofludimus hemicalcium 还可通过靶向 FXR 用于脂肪肝的研究。

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Vidofludimus hemicalcium Chemical Structure

Vidofludimus hemicalcium Chemical Structure

CAS No. : 1354012-90-0

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vidofludimus (4sc-101; SC12267) hemicalcium is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR). Vidofludimus hemicalcium, as an immunomodulatory agent, can be used for the research of autoimmune disorders such as inflammatory bowel disease (IBD). Vidofludimus hemicalcium also can be used for the research of fatty liver by targeting FXR[1][2][3].

IC50 & Target

EC50: 450 nM (FXR)[1]
IC50: 160 nM (human DHODH)[3]

体外研究
(In Vitro)

Vidofludimus hemicalcium (0-1 µM) 以浓度依赖性方式选择性激活 FXR,EC50 值约为 450 nM,可诱导各种共激活因子 LXXLL 基序的募集[1].
Vidofludimus hemicalcium (0-8 μM) 通过抑制 IKK-IκB-NF-κB 通路阻断 p65 的核转位[1]
Vidofludimus hemicalcium 对人 DHODH 具有抑制活性,IC50 值为 160 nM[2]
Vidofludimus hemicalcium 在体外抑制二氢乳清酸脱氢酶和淋巴细胞增殖[3]
Vidofludimus hemicalcium 在体外抑制白细胞介素 (IL)-17 分泌,与对淋巴细胞增殖的影响无关[3]
Vidofludimus hemicalcium 在体外完全阻断 IL-23 + IL-1β 刺激的结肠条分泌 IL-17[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Vidofludimus hemicalcium(腹腔注射;每天一次;持续 14 天)在体内以 FXR 依赖性方式对葡聚糖硫酸钠 (DSS) 诱导的结肠炎产生影响[1]
Vidofludimus hemicalcium(口服;60 mg/kg;持续 6 天)有效改善大鼠 TNBS 诱导的结肠炎的许多参数,并对结肠 STAT3IL-17 具有抑制作用[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

375.40

Formula

C20H18FNO4.1/2Ca

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Vidofludimus hemicalcium
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