2. Metabolic Enzyme/Protease
  3. Dihydroorotate Dehydrogenase
  4. DHODH-IN-21

DHODH-IN-21 (compound 19) 是一种具有口服活性的选择性二氢乳酸脱氢酶 (DHODH) 抑制剂，其 IC50 值为 1.1 nM。DHODH-IN-21 具有抗癌活性，可用于急性髓性白血病 (AML) 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

DHODH-IN-21 Chemical Structure

DHODH-IN-21 Chemical Structure

CAS No. : 2450341-39-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

DHODH-IN-21 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML)[1].

IC50 & Target[1]

Mouse DHODH

140 nM (IC50)

Rat DHODH

1580 nM (IC50)

Dog DHODH

8.5 nM (IC50)

Monkey DHODH

1.6 nM (IC50)

体外研究
(In Vitro)

DHODH-IN-21 (compound 19) inhibits the proliferation of MOLM-13 and THP-1 cells with the IC50 values of 2.0 nM and 5.0 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DHODH-IN-21 相关抗体:
体内研究
(In Vivo)

DHODH-IN-21 (compound 19) (p.o., 10 or 20 mg/kg, everyday, 5 days) inhibits tumor growth in a dose-dependent manner but no effect on body weight in female NSG mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human MOLM-13 AML xenograft model in female NSG mice[1]
Dosage: 10, 20 mg/kg
Administration: Oral administration; everyday; 5 days
Result: Inhibited tumor volume size by 44% and 60% at 10 mg/kg and 20 mg/kg respectively.
Animal Model: Mouse, rat[1]
Dosage:
Administration: 2 mg/kg i.v. or 10 mg/kg p.o.
Result: The pharmacokinetic parameters of DHODH-IN-21 (compound 19)
Parameter Mouse Rat
CL (mL/min/kg) 11 32
Vdss (L/kg) 1.3 2.3
t1/2(h) 2.3 2.0
Cmax (ng/mL) 4047 1713
tmax(h) 0.42 1.7
AUC0→inf(h•ng/mL) 16,066 9214
F% 103 167
分子量

518.85

Formula

C20H19ClF4N6O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DHODH-IN-21 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-212450341-39-4Dihydroorotate DehydrogenaseDHODHDHODH inhibitordihydroorotate dehydrogenaseanticanceracute myeloid leukaemiaAMLInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
DHODH-IN-21
目录号：
HY-149030
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z