1. Gene
  2. Mesd - mesoderm development LRP chaperone Gene

Mesd - mesoderm development LRP chaperone Gene

种属: Mus musculus

同用名: msd; mesd; Mesdc2; mKIAA0081; 2210015O11Rik

基因 ID: 67943 | 基因类型: protein coding

关于 Mesd

功能概要

Enables identical protein binding activity and low-density lipoprotein particle receptor binding activity. Involved in phagocytosis and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within protein folding and protein localization to cell surface. Located in plasma membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; lung; and ventricular layer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 20. Orthologous to human MESD (mesoderm development LRP chaperone). [provided by Alliance of Genome Resources, Apr 2022]

Mesd 基因产物(2)

mRNA Protein Name
NM_001374090.1 NP_001361019.1 LRP chaperone MESD isoform 2
NM_023403.4 NP_075892.3 LRP chaperone MESD isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21397184 MGI
enables low-density lipoprotein particle receptor binding IPI
IPI: 通过物理相互作用推断
16263759 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16989816 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phagocytosis IMP
IMP: 通过突变表型推断
27184668 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: 通过突变表型推断
24140340 MGI
acts upstream of or within protein folding IDA
IDA: 通过直接分析推断
16263759 MGI
involved in protein folding IMP
IMP: 通过突变表型推断
21397183 MGI
acts upstream of or within protein localization to cell surface IDA
IDA: 通过直接分析推断
18505367 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
16263759 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

LRP chaperone MESD

LDLR chaperone MESD

mesoderm development candidate 2

Mesd 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Mesd Q9ERE7 LRP5 Homo sapiens O75197 15143163
种属内
Mesd Q9ERE7 Lrp5 Mus musculus Q91VN0 12581525
种属内
Mesd Q9ERE7 Mesd Mus musculus Q9ERE7 21397184
种属内
Mesd Q9ERE7 Mesd Mus musculus Q9ERE7 21397184
种属间
Mesd Q9ERE7 LRP6 Homo sapiens O75581 16989816
种属内
Mesd Q9ERE7 Lrp6 Mus musculus O88572 12581525
种属内
Mesd Q9ERE7 Mesd Mus musculus Q9ERE7
GMS
21397184
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mesd NCBI NCBI:23184