2. Gene
  3. TAF6 - TATA-box binding protein associated factor 6 Gene

TAF6 - TATA-box binding protein associated factor 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TATA-box 结合蛋白相关因子 6

种属: Homo sapiens

同用名: ALYUS; TAF2E; TAFII70; TAFII80; TAFII85; MGC:8964; TAFII-70; TAFII-80; TAF(II)70; TAF(II)80

基因 ID: 6878 | 基因类型: protein coding

关于 TAF6

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,107,070-100,127,171 (from NCBI)

This gene has 71 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 19.4), endometrium (RPKM 14.3) and 25 other tissues.

功能概要

RNA 聚合酶 II 启动转录需要 70 多种多肽的活性。协调这些活动的蛋白质是转录因子 IID (TFIID) ，它与核心启动子结合以正确定位聚合酶，充当组装转录复合物其余部分的支架，并充当调节信号的通道。 TFIID 由 TATA 结合蛋白 (TBP) 和一组称为 TBP 相关因子或 TAF 的进化保守蛋白组成。 TAF 可能参与基础转录，充当共激活因子，在启动子识别中发挥作用或修饰一般转录因子 (GTF) 以促进复杂的组装和转录起始。该基因编码 TFIID 的较小亚基之一，该亚基与 TBP 弱结合，但与 TFIID 的最大亚基 TAF1 强结合。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 6 月]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

TAF6 基因产物(10)

mRNA Protein Name
NM_001190415.2 NP_001177344.1 transcription initiation factor TFIID subunit 6 isoform epsilon
NM_001364998.1 NP_001351927.1 transcription initiation factor TFIID subunit 6 isoform alpha
NM_001364999.1 NP_001351928.1 transcription initiation factor TFIID subunit 6 isoform alpha
NM_001365000.1 NP_001351929.1 transcription initiation factor TFIID subunit 6 isoform delta
NM_001365001.1 NP_001351930.1 transcription initiation factor TFIID subunit 6 isoform delta
NM_001365002.1 NP_001351931.1 transcription initiation factor TFIID subunit 6 isoform delta
NM_001365003.1 NP_001351932.1 transcription initiation factor TFIID subunit 6 isoform delta
NM_001365004.1 NP_001351933.1 transcription initiation factor TFIID subunit 6 isoform zeta
NM_005641.4 NP_005632.1 transcription initiation factor TFIID subunit 6 isoform alpha
NM_139315.3 NP_647476.1 transcription initiation factor TFIID subunit 6 isoform alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15601843 GOA
contributes to RNA polymerase II general transcription initiation factor activity IDA
IDA: 通过直接分析推断
9603525 GOA
enables RNA polymerase II general transcription initiation factor activity IDA
IDA: 通过直接分析推断
15328371 GOA
enables aryl hydrocarbon receptor binding IPI
IPI: 通过物理相互作用推断
15641800 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7667268 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA-templated transcription initiation IDA
IDA: 通过直接分析推断
9603525 GOA
involved in RNA polymerase II preinitiation complex assembly IPI
IPI: 通过物理相互作用推断
27007846 GOA
involved in mRNA transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17884155 GOA
involved in negative regulation of cell cycle IDA
IDA: 通过直接分析推断
15328371 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15328371 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
11583621 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
20096117 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: 通过直接分析推断
11583621 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9603525 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: 通过直接分析推断
9603525 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MLL1 complex IDA
IDA: 通过直接分析推断
15960975 GOA
located in nucleus EXP
EXP: 通过实验结果推断
23332750 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18628956 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
15641800 GOA
part of transcription factor TFIID complex IDA
IDA: 通过直接分析推断
8262073 GOA
part of transcription factor TFIID complex IPI
IPI: 通过物理相互作用推断
23332750 GOA
part of transcription factor TFTC complex IDA
IDA: 通过直接分析推断
9603525 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAF6 蛋白结构

TAF

TAF: TATA box binding protein associated factor (TAF) (11 - 76)

TAF6_C

TAF6_C: TAF6 C-terminal HEAT repeat domain (308 - 398)

  • 0
  • 200
  • 400
  • 600
  • 677 a.a.
蛋白主名 其他名称

transcription initiation factor TFIID subunit 6

RNA polymerase II TBP-associated factor subunit E

TAF6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
TAF6 P49848 PB1 Influenza A virus Q1K9H5
Pull Down
21994455
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alazami-Yuan Syndrome

ALYUS
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Cornelia De Lange Syndrome 1

De Lange Syndrome

CDLS1

Cdl

Cdls

Typus Degenerativus Amstelodamensis

Brachmann-De Lange Syndrome

Bdls

Amstelodamensis Typus Degenerativus

Cornelia De Lange Syndrome, Type 1
Syndromic Intellectual Disability
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism

DYT3

Xdp

Lubag

Dystonia-Parkinsonism, X-Linked

Torsion Dystonia-Parkinsonism, Filipino Type

Dyt-Taf1

X-Linked Dystonia-Parkinsonism Syndrome

X-Linked Torsion Dystonia-Parkinsonism Syndrome

Dystonia Musculorum Deformans

X-Linked Dystonia-Parkinsonism/Lubag

Lubag Syndrome

Dystonia-3

Torsion Dystonia-Parkinsonism Filipino Type

X-Linked Torsion Dystonia 3

Dystonia, Torsion, X-Linked, Type 3
Kbg Syndrome

KBGS

Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies

Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies

Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies

Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome

Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14173 TAF6 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14174 TAF6L Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TAF6 VGNC VGNC:47085
Felis catus TAF6 VGNC VGNC:65935
Bos taurus TAF6 VGNC VGNC:35577
Macaca mulatta TAF6 VGNC VGNC:78093
Mus musculus TAF6 MGD MGI:109129
Rattus norvegicus TAF6 RGD RGD:1311608
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