TESK1 - testis associated actin remodelling kinase 1 Gene

中文名称：睾丸相关肌动蛋白重塑激酶 1

种属: Homo sapiens

关于 TESK1

功能概要

该基因产物是一种丝氨酸/苏氨酸蛋白激酶，包含一个 N 端蛋白激酶结构域和一个 C 端富含脯氨酸的结构域。它的蛋白激酶结构域与含有 LIM 基序的蛋白激酶 (LIMKs) 的结构域最密切相关。编码的蛋白可在体外磷酸化髓鞘碱性蛋白和组蛋白。小鼠基因的睾丸生殖细胞特异性表达和表达的发育模式表明该基因在精子发生的减数分裂阶段和之后起着重要作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 12 月]

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]