2. Gene
  3. SETD7 - SET domain containing 7, histone lysine methyltransferase Gene

SETD7 - SET domain containing 7, histone lysine methyltransferase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含 SET 结构域 7，组蛋白赖氨酸甲基转移酶

种属: Homo sapiens

同用名: KMT7; SET7; SET9; SET7/9

基因 ID: 80854 | 基因类型: protein coding

关于 SETD7

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,492,974-139,556,219 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 7 paralogues. Ubiquitous expression in fat (RPKM 22.9), prostate (RPKM 16.7) and 24 other tissues.

功能概要

启用组蛋白-赖氨酸 N-甲基转移酶活性和 p53 结合活性。参与肽基-赖氨酸二甲基化和肽基-赖氨酸单甲基化。在对 DNA 损伤刺激和异染色质组织的细胞反应的上游或内部起作用。位于染色体和核仁中。 [由基因组资源联盟提供，2022 年 4 月]

Enables histone-lysine N-methyltransferase activity and p53 binding activity. Involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Acts upstream of or within cellular response to DNA damage stimulus and heterochromatin organization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

SETD7 基因产物(3)

mRNA Protein Name
NM_001306199.2 NP_001293128.1 histone-lysine N-methyltransferase SETD7 isoform 2
NM_001306200.2 NP_001293129.1 histone-lysine N-methyltransferase SETD7 isoform 3
NM_030648.4 NP_085151.1 histone-lysine N-methyltransferase SETD7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H3 methyltransferase activity IDA
IDA: 通过直接分析推断
16415881 GOA
enables histone methyltransferase activity IDA
IDA: 通过直接分析推断
17707234 GOA
enables p53 binding IPI
IPI: 通过物理相互作用推断
17108971 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12540855 GOA
enables protein-lysine N-methyltransferase activity IDA
IDA: 通过直接分析推断
16415881 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IDA
IDA: 通过直接分析推断
23509280 GOA
acts upstream of or within heterochromatin organization IDA
IDA: 通过直接分析推断
23509280 GOA
involved in peptidyl-lysine dimethylation IDA
IDA: 通过直接分析推断
17108971 GOA
involved in peptidyl-lysine monomethylation IDA
IDA: 通过直接分析推断
17108971 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SETD7 蛋白结构

MORN

MORN: MORN repeat (19 - 34)

MORN

MORN: MORN repeat (36 - 58)

MORN

MORN: MORN repeat (60 - 81)

MORN

MORN: MORN repeat (106 - 127)

SET

SET: SET domain (229 - 336)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
蛋白主名 其他名称

histone-lysine N-methyltransferase SETD7

H3-K4-HMTase SETD7

SETD7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SETD7 Q8WTS6 SIRT1 Homo sapiens Q96EB6
Methyltransferase Ass
21245319
种属内
SETD7 Q8WTS6 SIRT1 Homo sapiens Q96EB6
Pull Down
21245319
种属内
SETD7 Q8WTS6 SIRT1 Homo sapiens Q96EB6
Anti Tag CoIP
21245319
种属内
SETD7 Q8WTS6 TP53 Homo sapiens P04637
Radiolabeled Methyl
16415881
种属内
SETD7 Q8WTS6 TP53 Homo sapiens P04637
Methyltransferase Ass
17805299
种属内
SETD7 Q8WTS6 TP53 Homo sapiens P04637
Methyltransferase Ass
21245319
种属内
SETD7 Q8WTS6 TP53 Homo sapiens P04637
Pull Down
21245319
种属内
SETD7 Q8WTS6 RB1 Homo sapiens P06400
Methyltransferase Ass
21119616
种属内
SETD7 Q8WTS6 TAF10 Homo sapiens Q12962
X-Ray Diffraction
16415881
种属内
SETD7 Q8WTS6 TAF10 Homo sapiens Q12962
Radiolabeled Methyl
16415881
种属内
SETD7 Q8WTS6 DNMT1 Homo sapiens P26358
Methyltransferase Ass
19282482
种属内
SETD7 Q8WTS6 DNMT1 Homo sapiens P26358
Pull Down
19282482
种属内
SETD7 Q8WTS6 RELA Homo sapiens Q04206
Methyltransferase Ass
19262565
种属内
SETD7 Q8WTS6 RELA Homo sapiens Q04206
Anti Tag CoIP
19262565
种属内
SETD7 Q8WTS6 RELA Homo sapiens Q04206
Pull Down
19262565
种属内
SETD7 Q8WTS6 RELA Homo sapiens Q04206
Anti Bait CoIP
19262565
种属内
SETD7 Q8WTS6 SERTAD1 Homo sapiens Q9UHV2
Y2H
21988832
种属内
SETD7 Q8WTS6 H3C1 Homo sapiens P68431
X-Ray Diffraction
12540855
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SETD7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76062 SETD7 Protein, Human (His) Q8WTS6/NP_085151.1 (D2-K366) ≥95%

SETD7 抗体

目录号 产品名 应用 反应物种
HY-P83151 SETD7 Antibody (YA2896) WB, IP Human, Mouse, Rat
HY-P84685 SETD7 Antibody (YA4382) WB, FC, ELISA Human, Rat, Monkey
HY-P84686 SETD7 Antibody (YA4383) WB, IHC-P, ELISA Human, Rat, Monkey

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18627A PFI-2 hydrochloride Inhibitor 99.48% 否
HY-13807 UNC0646 Inhibitor 99.38% 否
HY-148817 WDR5-0102 Inhibitor 97.07% 否
HY-18627 PFI-2 Inhibitor / 否
HY-110196 (S)-PFI-2 hydrochloride Inhibitor / 否
HY-156455 SETD7-IN-1 Inhibitor / 否
HY-RS12747 SETD7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18842 Setd7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25334 Setd7 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SETD7 VGNC VGNC:46058
Rattus norvegicus SETD7 RGD RGD:1586346
Mus musculus SETD7 MGD MGI:1920501
Bos taurus SETD7 VGNC VGNC:34497
Felis catus SETD7 VGNC VGNC:65046
Macaca mulatta SETD7 VGNC VGNC:77348
Others SETD7 NCBI
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