CAST - calpastatin Gene

中文名称：钙抑素

种属: Homo sapiens

同用名: BS-17; PLACK

基因 ID: 831 | 基因类型: protein coding

关于 CAST

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:96,662,037-96,774,683 (from NCBI)

This gene has 59 transcripts (splice variants), 206 orthologues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 82.1), heart (RPKM 55.7) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种内源性钙蛋白酶 (钙依赖性半胱氨酸蛋白酶) 抑制剂。它由一个 N 末端结构域 L 和四个重复的钙蛋白酶抑制结构域 (结构域 1-4) 组成，并参与淀粉样前体蛋白的蛋白水解。钙蛋白酶/钙蛋白酶抑制素系统参与许多膜融合事件，例如神经囊泡胞吐作用以及血小板和红细胞聚集。编码的蛋白质也被认为会影响编码结构或调节蛋白的基因的表达水平。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2010 年 6 月]

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

CAST 基因产物(22)

mRNA	Protein	Name
NM_001042440.5	NP_001035905.1	calpastatin isoform f
NM_001042441.3	NP_001035906.1	calpastatin isoform g
NM_001042442.3	NP_001035907.1	calpastatin isoform h
NM_001042443.3	NP_001035908.1	calpastatin isoform i
NM_001042444.3	NP_001035909.1	calpastatin isoform j
NM_001042445.3	NP_001035910.1	calpastatin isoform k
NM_001042446.3	NP_001035911.1	calpastatin isoform l
NM_001190442.2	NP_001177371.1	calpastatin isoform m
NM_001284212.4	NP_001271141.1	calpastatin isoform n
NM_001284213.4	NP_001271142.1	calpastatin isoform o
NM_001330626.2	NP_001317555.1	calpastatin isoform p
NM_001330627.2	NP_001317556.1	calpastatin isoform q
NM_001330628.2	NP_001317557.1	calpastatin isoform r
NM_001330629.2	NP_001317558.1	calpastatin isoform s
NM_001330630.2	NP_001317559.1	calpastatin isoform t
NM_001330631.2	NP_001317560.1	calpastatin isoform m
NM_001330632.2	NP_001317561.1	calpastatin isoform u
NM_001330633.2	NP_001317562.1	calpastatin isoform v
NM_001330634.2	NP_001317563.1	calpastatin isoform w
NM_001375317.1	NP_001362246.1	calpastatin isoform x
NM_001750.7	NP_001741.4	calpastatin isoform a
NM_173060.5	NP_775083.1	calpastatin isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium-dependent cysteine-type endopeptidase inhibitor activity	IMP IMP: 通过突变表型推断	2407243	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17474147	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in inhibition of cysteine-type endopeptidase activity	IMP IMP: 通过突变表型推断	2407243	GOA
involved in negative regulation of type B pancreatic cell apoptotic process	IDA IDA: 通过直接分析推断	15044459	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	14559243	GOA
located in membrane	IDA IDA: 通过直接分析推断	14559243	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAST 蛋白结构

Calpain_inhib

0
200
400
600
708 a.a.

蛋白主名

其他名称

calpastatin

calpain inhibitor

CAST 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CAST	P20810	NCK1	Homo sapiens	P16333	Peptide Array	17474147

种属间: 跨种属相互作用 种属内: 同种属相互作用

CAST 抗体

目录号	产品名	应用	反应物种
HY-P80042	Calpastatin Antibody (YA814)	WB, ICC/IF, IHC-P	Human
HY-P81471	Calpastatin Antibody (YA1216)	IHC-P	Human

关联疾病

疾病名称

别名

Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads

PLACK	Peeling Skin-Leukonychia-Acral Punctate Keratoses-Cheilitis-Knuckle Pads Syndrome
Plack Syndrome

Cheilitis

Knuckle Pads

Garrod Pads

Inflammatory Bowel Disease 15

IBD15

Scrapie

Palmoplantar Keratoderma, Punctate Type Iii

Acrokeratoelastoidosis Of Costa	Ake
Punctate Palmoplantar Keratoderma Type Iii	PPKP3
Keratoderma, Palmoplantar, Punctate Type 3	Punctate Palmoplantar Hyperkeratosis Type 3
Punctate Palmoplantar Keratoderma Type 3	Rare Form Of Hirschsprung'S Disease
Acrokeratoelastoidosis	Collagenous Plaques Of Hands And Feet
Aganglionosis, Total Intestinal	Collagenous Plaques Of Hand And Feet
Palmoplantar Keratoderma, Punctate Type 3	Aganglionosis, Total Colonic
Ntia	Near-Total Intestinal Aganglionosis
Tia

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2a

Leyden-Moebius Muscular Dystrophy	Lgmd2a
Limb-Girdle Muscular Dystrophy Due To Calpain Deficiency	Muscular Dystrophy, Limb-Girdle, Type 2a
Pelvofemoral Muscular Dystrophy	Primary Calpainopathy

Keratoderma, Palmoplantar, With Deafness

Palmoplantar Keratoderma-Deafness Syndrome	Palmoplantar Keratoderma With Deafness
Palmoplantar Hyperkeratosis-Deafness Syndrome	Palmoplantar Hyperkeratosis-Hearing Loss Syndrome
Palmoplantar Keratoderma-Hearing Loss Syndrome	Ppk-Deafness Syndrome
Keratoderma Palmoplantar Deafness	Diffuse Palmoplantar Keratoderma With Deafness
Focal Palmoplantar Keratoderma With Sensorineural Deafness	Hereditary Palmoplantar Keratoderma With Deafness
Keratoderma Palmoplantar, With Deafness	Palmoplantar Keratoderma And Sensorineural Deafness
Ppk With Deafness	PPKDFN
Keratoderma Palmoplantar, Deafness

Hemoglobin E Disease

Hemoglobin E

Hb-E Disease

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N10637	N-Acetyldopamine dimer-1		/	否
HY-N12703	N-Acetyldopamine dimmers A		/	否
HY-RS01978	CAST Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS04477	ERC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17878	Cast Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24347	Cast Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CAST	MGD	MGI:1098236
Felis catus	CAST	VGNC	VGNC:60390
Macaca mulatta	CAST	VGNC	VGNC:70551
Rattus norvegicus	CAST	RGD	RGD:2278
Canis familiaris	CAST	VGNC	VGNC:38742
Bos taurus	CAST	VGNC	VGNC:26790
Others	CAST	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CAST - calpastatin Gene

关于 CAST

功能概要

CAST 基因产物(22)

CAST 蛋白结构

CAST 蛋白互作信息

CAST 抗体

关联疾病

直系同源

热门区域

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CAST - calpastatin Gene

关于 CAST

功能概要

CAST 基因产物(22)

CAST 蛋白结构

CAST 蛋白互作信息

CAST 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z