2. Gene
  3. DGAT2 - diacylglycerol O-acyltransferase 2 Gene

DGAT2 - diacylglycerol O-acyltransferase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二酰基甘油 O-酰基转移酶 2

种属: Homo sapiens

同用名: ARAT; HMFN1045; GS1999FULL

基因 ID: 84649 | 基因类型: protein coding

关于 DGAT2

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:75,768,778-75,801,534 (from NCBI)

This gene has 9 transcripts (splice variants), 221 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in fat (RPKM 381.0), liver (RPKM 87.8) and 1 other tissue.

功能概要

该基因编码两种酶中的一种，这两种酶催化甘油三酯合成中的最终反应，其中甘油二酯与长链脂肪酰辅酶 A 共价结合。编码的蛋白质在低浓度氯化镁下催化该反应，而另一种酶在高浓度氯化镁下具有高活性。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 12 月]

This gene encodes one of two Enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the Other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

DGAT2 基因产物(2)

mRNA Protein Name
NM_001253891.2 NP_001240820.1 diacylglycerol O-acyltransferase 2 isoform 2
NM_032564.5 NP_115953.2 diacylglycerol O-acyltransferase 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables diacylglycerol O-acyltransferase activity EXP
EXP: 通过实验结果推断
11481335 GOA
enables diacylglycerol O-acyltransferase activity IDA
IDA: 通过直接分析推断
11481335 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
30970241 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in diacylglycerol metabolic process IDA
IDA: 通过直接分析推断
11481335 GOA
involved in long-chain fatty-acyl-CoA metabolic process IDA
IDA: 通过直接分析推断
11481335 GOA
involved in monoacylglycerol biosynthetic process IDA
IDA: 通过直接分析推断
28420705 GOA
involved in triglyceride biosynthetic process IDA
IDA: 通过直接分析推断
11481335 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
14521909 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
27184406 GOA
located in lipid droplet IDA
IDA: 通过直接分析推断
27184406 GOA
located in membrane IDA
IDA: 通过直接分析推断
11481335 GOA
located in perinuclear endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
27184406 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DGAT2 蛋白结构

DAGAT

DAGAT: Diacylglycerol acyltransferase (92 - 388)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

diacylglycerol O-acyltransferase 2

acyl-CoA retinol O-fatty-acyltransferase

关联疾病

疾病名称 别名
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Dgat2 Mutation

Cmt2 Due To Dgat2 Mutation
Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2
Pellagra

Niacin Deficiency

Niacin-Tryptophan Deficiency

Pellagroid Syndrome
Familial Hyperlipidemia

Familial Hyperlipoproteinemia

Hyperlipidaemia

Hyperlipoproteinemias

Hyperlipidemia

Hyperlipemia

Hyperlipidemias
Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash
Chanarin-Dorfman Syndrome

Neutral Lipid Storage Disease

CDS

Neutral Lipid Storage Disease With Ichthyosis

Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation

Triglyceride Storage Disease With Ichthyosis

Nlsdi

Ichthyotic Neutral Lipid Storage Disease

Dorfman-Chanarin Syndrome

Dcs

Chanarin-Dorfman Disease

Ichthyosiform Erythroderma With Leukocyte Vacuolation

Lipidosis With Triglyceride Storage Disease

Disorder Of Cornification 12

Dorfman Chanarin Syndrome

Neutral Lipid Storage Disease With Ichthyotic

Dorfman-Chanarin Disease
Choline Deficiency Disease

Choline Deficiency
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Non-Alcoholic Steatohepatitis

Nonalcoholic Steatohepatitis

Nash

Nash - [Non-Alcoholic Steatohepatitis]

Non-Alcoholic Steatohepatosis
Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence

Fads

Fetal Akinesia Sequence

FADS1

Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

Pena-Shokeir Syndrome Type 1

Fetal Akinesia Deformation Sequence Syndrome

Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

Pena-Shokeir Syndrome, Type I

Foetal Akinesia Deformation Sequence Syndrome

Foetal Akinesia Sequence

Fetal Akinesia Deformation Sequence Syndrome 1

Pena-Shokeir Syndrome, Type 1

Pena Shokeir Syndrome, Type 1

Akinesia, Fetal, Deformation Sequence

Akinesia, Fetal, Deformation Sequence, Type 1

Pena-Shokeir Syndrome Type I
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108341A PF-06424439 methanesulfonate Inhibitor 99.85% 否
HY-32219 T863 Inhibitor 99.83% 否
HY-108341 PF-06424439 Inhibitor 99.89% 否
HY-110381 JNJ-DGAT2-A Inhibitor 98.26% 否
HY-156259 PF-07202954 Inhibitor 98.82% 否
HY-159698A IONIS-DGAT 2Rx sodium Inhibitor 96.10% 否
HY-23199 H2-003 Inhibitor 99.53% 否
HY-169499 (R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid / 否
HY-118386 H2-005 / 否
HY-145624 Obeversen Inhibitor / 否
HY-159698 IONIS-DGAT 2Rx Inhibitor / 否
HY-162854 Diacylglycerol acyltransferase inhibitor-2 Inhibitor / 否
HY-162978 DGAT2-IN-3 Inhibitor / 否
HY-RS03711 DGAT2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16657 Dgat2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23092 Dgat2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DGAT2 MGD MGI:1915050
Canis familiaris DGAT2 VGNC VGNC:39913
Felis catus DGAT2 VGNC VGNC:102874
Bos taurus DGAT2 VGNC VGNC:28021
Macaca mulatta DGAT2 VGNC VGNC:71637
Rattus norvegicus DGAT2 RGD RGD:620329
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