KMO - kynurenine 3-monooxygenase Gene

中文名称：犬尿氨酸 3-单加氧酶

种属: Homo sapiens

同用名: dJ317G22.1

基因 ID: 8564 | 基因类型: protein coding

关于 KMO

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:241,532,378-241,595,642 (from NCBI)

This gene has 10 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in liver (RPKM 11.5), kidney (RPKM 9.8) and 20 other tissues.

功能概要

该基因编码一种线粒体外膜蛋白，可催化 L-色氨酸代谢物 L-犬尿氨酸的羟基化，形成 L-3-羟基犬尿氨酸。对酵母的研究将该基因确定为亨廷顿病的治疗靶标。[RefSeq 提供，2011 年 10 月]

This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]

KMO 基因产物(2)

mRNA	Protein	Name
NM_001410944.1	NP_001397873.1	kynurenine 3-monooxygenase isoform 2
NM_003679.5	NP_003670.2	kynurenine 3-monooxygenase isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables FAD binding	IDA IDA: 通过直接分析推断	29429898	GOA
enables NAD(P)H oxidase H2O2-forming activity	IDA IDA: 通过直接分析推断	10672018	GOA
enables flavin adenine dinucleotide binding	IDA IDA: 通过直接分析推断	10672018	GOA
enables kynurenine 3-monooxygenase activity	IDA IDA: 通过直接分析推断	9237672	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in NAD metabolic process	IDA IDA: 通过直接分析推断	23575632	GOA
involved in kynurenine metabolic process	IDA IDA: 通过直接分析推断	10672018	GOA
involved in response to salt stress	IDA IDA: 通过直接分析推断	10672018	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KMO 蛋白结构

FAD_binding_3

0
100
200
300
400
486 a.a.

蛋白主名

其他名称

kynurenine 3-monooxygenase

kynurenine 3-hydroxylase

关联疾病

疾病名称

别名

Transient Cerebral Ischemia

Transient Ischemic Attack	Transient Ischemic Attacks
Tia	Tia - Transient Ischaemic Attack
Transient Cerebral Ischaemia	Ischemic Attack, Transient
Intermittent Cerebral Ischemia	Tia - [Transient Ischaemic Attack]
Intermittent Cerebral Ischaemia	Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Streptococcal Meningitis

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Intracranial Vasospasm

Vasospasm, Intracranial

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12347	Ro 61-8048	Inhibitor	99.76%	否
HY-112179	GSK180	Inhibitor	98.34%	否
HY-W748591	Cannflavin A	Inhibitor	99.20%	否
HY-15500	JM6	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	KMO	MGD	MGI:2138151
Macaca mulatta	KMO	VGNC	VGNC:74197
Canis familiaris	KMO	VGNC	VGNC:42488
Rattus norvegicus	KMO	RGD	RGD:620610
Bos taurus	KMO	VGNC	VGNC:30689
Felis catus	KMO	VGNC	VGNC:67970
Others	KMO	NCBI

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