B4GALT5 - beta-1,4-galactosyltransferase 5 Gene

中文名称：β-1,4-半乳糖基转移酶 5

种属: Homo sapiens

同用名: gt-V; B4Gal-T5; beta4Gal-T5; beta4GalT-V; BETA4-GALT-IV

关于 B4GALT5

功能概要

该基因是七个 beta-1,4-半乳糖基转移酶 (beta4GalT) 基因之一。它们编码 II 型膜结合糖蛋白，这些糖蛋白似乎对供体底物 UDP-半乳糖具有专一性；所有都将半乳糖以 beta1,4 键转移到类似的受体糖：GlcNAc、Glc 和 Xyl。每个 beta4GalT 在不同糖缀合物和糖结构的生物合成中具有独特的功能。作为 II 型膜蛋白，它们具有一个 N 端疏水信号序列，该序列将蛋白质引导至高尔基体，然后保持未切割状态以充当跨膜锚。通过序列相似性，beta4GalTs 形成四组：beta4GalT1 和 beta4GalT2、beta4GalT3 和 beta4GalT4、beta4GalT5 和 beta4GalT6 以及 beta4GalT7。该基因编码的酶的功能尚不清楚。该基因之前被命名为 B4GALT4，但被重命名为 B4GALT5。在文献中它也被称为 beta4GalT2。[RefSeq 提供，2008 年 7 月]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq, Jul 2008]