2. Gene
  3. SIGLEC6 - sialic acid binding Ig like lectin 6 Gene

SIGLEC6 - sialic acid binding Ig like lectin 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：唾液酸结合 Ig样凝集素 6

种属: Homo sapiens

同用名: CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327

基因 ID: 946 | 基因类型: protein coding

关于 SIGLEC6

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,517,819-51,531,670 (from NCBI)

This gene has 9 transcripts (splice variants), 66 orthologues and 16 paralogues. Biased expression in placenta (RPKM 50.1) and lung (RPKM 2.3).

功能概要

该基因编码 Siglec (唾液酸结合免疫球蛋白样凝集素) 蛋白质家族的成员。编码的跨膜受体结合唾液酸-TN 聚糖和瘦素。编码蛋白的胎盘表达在先兆子痫中上调。[RefSeq 提供，2016 年 7 月]

This gene encodes a member of the Siglec (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and Leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

SIGLEC6 基因产物(6)

mRNA Protein Name
NM_001177547.3 NP_001171018.1 sialic acid-binding Ig-like lectin 6 isoform 4
NM_001177548.3 NP_001171019.1 sialic acid-binding Ig-like lectin 6 isoform 5 precursor
NM_001177549.3 NP_001171020.1 sialic acid-binding Ig-like lectin 6 isoform 6 precursor
NM_001245.7 NP_001236.4 sialic acid-binding Ig-like lectin 6 isoform 1 precursor
NM_198845.6 NP_942142.3 sialic acid-binding Ig-like lectin 6 isoform 2 precursor
NM_198846.6 NP_942143.3 sialic acid-binding Ig-like lectin 6 isoform 3 precursor

SIGLEC6 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (32 - 131)

ig

ig: Immunoglobulin domain (163 - 217)

I-set

I-set: Immunoglobulin I-set domain (254 - 336)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
蛋白主名 其他名称

sialic acid-binding Ig-like lectin 6

CD33 antigen-like 1

重组 SIGLEC6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71031 Siglec-6 Protein, Human (HEK293, Fc) O43699-3 (E27-V331) ≥95%
HY-P700825 Siglec-6 Protein, Human (HEK293, His-Avi) O43699-3 (Q27-V331) ≥95%

关联疾病

疾病名称 别名
Non-Gestational Choriocarcinoma

Choriocarcinoma, Non-Gestational
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12904 SIGLEC6 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SIGLEC6 MGD MGI:99440
Rattus norvegicus SIGLEC6 RGD RGD:1305432
Macaca mulatta SIGLEC6 VGNC VGNC:77216
Others SIGLEC6 NCBI
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