1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. GI-530159

GI-530159 

目录号: HY-W013712
产品使用指南

GI-530159 是选择性的 TREK1 (K2P2.1)TREK2 (K2P10.1) 通道的开放剂,对 TREK1 的EC50 为 0.76 μM。GI-530159 显示了 TREK1/2 对 TRAAK,TASK3 和其他钾离子通道的选择性。GI-530159 降低大鼠背根神经节神经元兴奋性。

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GI-530159 Chemical Structure

GI-530159 Chemical Structure

CAS No. : 69563-88-8

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥550 In-stock
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Description

GI-530159 is a selective, mechanosensitive opener of TREK1 (K2P2.1) and TREK2 (K2P10.1) channels, with an EC50 of 0.76 μM for TREK1. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels. GI-530159 reduces rat dorsal root ganglion neuron excitability[1].

Molecular Weight

518.45

Formula

C₂₇H₂₀F₆N₂O₂

CAS No.

69563-88-8

SMILES

FC(C(C1=CC=C(OC2=CC=C(N)C=C2)C=C1)(C3=CC=C(OC4=CC=C(N)C=C4)C=C3)C(F)(F)F)(F)F

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (482.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9288 mL 9.6441 mL 19.2883 mL
5 mM 0.3858 mL 1.9288 mL 3.8577 mL
10 mM 0.1929 mL 0.9644 mL 1.9288 mL
*

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储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

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Keywords:

GI-530159GI530159GI 530159Potassium ChannelKcsAratdorsalrootganglionneuronexcitabilityDRGfiringfrequencyInhibitorinhibitorinhibit

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