1. Anti-infection
  2. HBV
  3. GLP-26

GLP-26 

目录号: HY-124614
产品使用指南

GLP-26 是一种 HBV 衣壳组装调节剂 (CAM),抑制 Hep AD38 系统中的 HBV DNA 复制 (IC50=3 nM), 并在 1 μM 时使 cccDNA 降低> 90%。GLP-26 破坏前基因组 RNA 的衣壳化,导致核衣壳解体,并减少 cccDNA 库。

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GLP-26 Chemical Structure

GLP-26 Chemical Structure

CAS No. : 2133017-36-2

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Description

GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1].

In Vitro

GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBV wild type, with EC50 values of 0.7 μM[2].

Cell Viability Assay[2]

Cell Line: HepNTCP-DL cells
Concentration: 0.7-1.7 μM
Incubation Time: 3 days
Result: Reduced secreted HBeAg in HepNTCP-DL cells.
Molecular Weight

373.35

Formula

C₁₉H₁₇F₂N₃O₃

CAS No.

2133017-36-2

SMILES

O=C(C1=C(C)C(C(C(NCC#C)=O)=O)=C(C)N1C)NC2=CC=C(F)C(F)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
GLP-26
目录号:
HY-124614
需求量:

GLP-26

Cat. No.: HY-124614