1. Anti-infection Metabolic Enzyme/Protease
  2. HIV Endogenous Metabolite
  3. Glycolithocholic acid 3-sulfate

Glycolithocholic acid 3-sulfate  (Synonyms: Glycolithocholate sulfate; Sulfolithocholylglycine; SLCG)

目录号: HY-113074 纯度: ≥98.0%
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Glycolithocholic acid 3-sulfate (SLCG) 是一种胆汁酸衍生物和甘胆酸的代谢物。Glycolithocholic acid 3-sulfate 抑制 HIV-1 的复制。Glycolithocholic acid 3-sulfate 可用于研究 HIV 感染和胆囊疾病。

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Glycolithocholic acid 3-sulfate Chemical Structure

Glycolithocholic acid 3-sulfate Chemical Structure

CAS No. : 15324-64-8

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  • 生物活性

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生物活性

Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease[1][2].

IC50 & Target

Microbial Metabolite

 

体外研究
(In Vitro)

Glycolithocholic acid 3-sulfate (100 μg/mL) 可保护 MT-4 细胞免受 HIV-1 诱导的细胞病变[1]
Glycolithocholic acid 3-sulfate (200 μg/mL) 对宿主细胞无毒性[1]
Glycolithocholic acid 3-sulfate 抑制 HIV-1 感染的 CEM 细胞中 HIV-1 抗原的表达[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Glycolithocholic acid 3-sulfate (24 μmoL/100 g;静脉注射,1 次) 诱导胆瘘的雄性 Wistar 大鼠肝内胆汁淤积,增加胆汁胆固醇分泌[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats with bile fistula[2]
Dosage: 24 μmoL/100 g
Administration: Intravenous injection; 24 μmoL/100 g
Result: Induced intrahepatic cholestasis and increased biliary cholesterol secretion.
分子量

513.69

Formula

C26H43NO7S

CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Glycolithocholic acid 3-sulfate 相关分类

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Glycolithocholic acid 3-sulfate
目录号:
HY-113074
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