2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. GNE-5152

GNE-5152 是一种正构 SARM1 碱基交换 (BE) 抑制剂。GNE-5152 在轻度激活条件下，以亚抑制浓度持续激活 SARM1，这种协同副作用会增加 NAD 的消耗，诱导轴突退化和神经退行性变，并释放皮层神经元中的神经丝轻链 (NfL)。GNE-5152 可用于神经退行性疾病研究。

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GNE-5152

GNE-5152 Chemical Structure

CAS No. : 3080315-83-6

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GNE-5152 相关抗体

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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  • 纯度 & 产品资料

  • 参考文献

生物活性

GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research[1].

分子量

365.38

Formula

C21H17F2N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GNE-5152 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

GNE-51523080315-83-6GNE5152GNE 5152Toll-like Receptor (TLR)OrthostericBase-exchangeBEInhibitorSARM1Subinhibitory concentrationsNADAxon degradationNfLNeurodegenerative diseasesinhibitorinhibit

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产品名称：
GNE-5152
目录号：
HY-176783
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