1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. GNE-5152

GNE-5152 是一种正构 SARM1 碱基交换 (BE) 抑制剂。GNE-5152 在轻度激活条件下,以亚抑制浓度持续激活 SARM1,这种协同副作用会增加 NAD 的消耗,诱导轴突退化和神经退行性变,并释放皮层神经元中的神经丝轻链 (NfL)。GNE-5152 可用于神经退行性疾病研究。

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GNE-5152

GNE-5152 Chemical Structure

CAS No. : 3080315-83-6

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生物活性

GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research[1].

分子量

365.38

Formula

C21H17F2N3O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
GNE-5152
目录号:
HY-176783
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