2. Stem Cell/Wnt PI3K/Akt/mTOR Metabolic Enzyme/Protease Neuronal Signaling
  3. GSK-3 Cytochrome P450 Amyloid-β Tau Protein
  4. GSK3β-IN-3

GSK3β-IN-3 是一种 ATP 竞争性 GSK-3β 抑制剂 (IC50 = 0.90 μM) 。GSK3β-IN-3 可降低 BR5706 菌株中 tau 蛋白的磷酸化水平，并减少 CL2006 菌株中的 Aβ 聚集体沉积，可用于阿尔茨海默病 (AD) 研究。

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GSK3β-IN-3

GSK3β-IN-3 Chemical Structure

CAS No. : 301359-45-5

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GSK3β-IN-3 相关抗体

Top Publications Citing Use of Products

查看 GSK-3 亚型特异性产品:

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GSK-3 GSK-3α GSK-3β

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50 = 0.90 μM). GSK3β-IN-3 can reduce the phosphorylation level of tau protein in the BR5706 strain and reduce the deposition of Aβ aggregates in the CL2006 strain, and can be used to research Alzheimer's disease (AD)[1].

IC50 & Target[1]

GSK3β

0.90 μM (IC50)

体外研究
(In Vitro)

GSK3β-IN-3 (Compound 66) (0.01-100 μM) 抑制 GSK-3β，IC50 = 0.90 μM[1]。

GSK3β-IN-3 (0-50 μM) 对 GSK-3β 酶表现出 ATP 竞争性抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GSK3β-IN-3 相关抗体:
体内研究
(In Vivo)

GSK3β-IN-3 (Compound 66) (10 μM) 可降低秀丽隐杆线虫 BR5706 菌株中 p-Tau (Ser396) 的水平[1]。

GSK3β-IN-3 (10 μM) 可增加秀丽隐杆线虫 CL2006 菌株中的鞭毛数量，并减少 Aβ 沉积[1]。

GSK3β-IN-3 在人微粒体中表现出良好的稳定性[1]。

GSK3β-IN-3 在 PAMPA-BBB 测试中具有穿过血脑屏障的潜力[1]。

GSK3β-IN-3 具有较高的血浆蛋白结合率，血浆蛋白结合率达 96.4%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

310.80

Formula

C14H15ClN2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK3β-IN-3 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

GSK3β-IN-3301359-45-5GSK-3Cytochrome P450Amyloid-βTau ProteinGlycogen synthase kinase-3Glycogen synthase kinase 3CYPsβ-amyloid peptideAβAbetaInhibitorAlzheimer's diseaseC. elegansinhibitorinhibit

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