2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO2-IN-1

IDO2-IN-1 是一种具有口服活性的强效吲哚胺 2,3- 双加氧酶 (IDO2) 抑制剂，IC50 为 112 nM。IDO2-IN-1 能够用于对炎症性自身免疫的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

IDO2-IN-1 Chemical Structure

IDO2-IN-1 Chemical Structure

CAS No. : 2803768-09-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥5717
In-stock
1 mg ￥2181
In-stock
5 mg ￥4800
In-stock
10 mg ￥7600
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

IDO2-IN-1 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO2-IN-1 is an orally active and potent Indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with an IC50 value of 112 nM. IDO2-IN-1 can be used for inflammatory autoimmunity research[1].

IC50 & Target

IDO1

411 nM (IC50)

IDO2

112 (IC50)

体外研究
(In Vitro)

IDO2-IN-1 (compound 22) shows stronger inhibition on IDO2 (IC50 =112 nM) over IDO1 (IC50 =411 nM)[1].
IDO2-IN-1 inhibits hIDO1 expression (EC50=633 nM) in HeLa cell-based IDO1/kynurenine assay, co-incubated with hIFN-γ (100 ng/mL final concentration), which is used for producing N-formylkynurenine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IDO2-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: HeLa cells line expressing hIDO1 induced by IFN-γ
Concentration: 1 nM-0.1 mM
Incubation Time: 48 hours
Result: Showed additional potency against IDO1 with an EC50 value of 633 nM.
体内研究
(In Vivo)

The Adjuvant arthritis (AA) model and Collagen-induced arthritis (CIA) model have similar pathogenesis and pathological characteristics to human rheumatoid arthritis (RA).
IDO2-IN-1 (compound 22) (100 mg/kg; p.o.; once dose) exhibits excellent anti-inflammatory activity, higher than naproxen, a prescription drug reducing pain, swelling, and joint stiffness from arthritis[1].
IDO2-IN-1 (25, 50, 100 mg/kg; i.p.; once daily, for 19 d) exhibits excellent inhibitory effect on mice paw swelling, shows efficacy in a collagen-induced arthritis model in mice[1].
IDO2-IN-1 (30, 60, 120 mg/kg; i.p.; once daily, for 15 d) inhibits joint inflammation and displays potential effect in autoimmune arthritis improvement[1].
Pharmacokinetic Profile in Rat[1]

Route Dose (mg/kg) T1/2/sub> (h) Tmax (h) Cmax (ng/mL) AUC(0-∞) (h•ng/mL) CL (mL/h/kg) Vz (mL/kg) MRT(0-∞) (h) F (%)
i.v. 1 0.69 / / 375.1 2673 2675 0.55 /
p.o. 10 2.02 0.75 153.8 670.5 / / 7.48 17.87

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xylene-induced ear swelling mouse model (ICR mice, male, 6 weeks old)[1]
Dosage: 100 mg/kg
Administration: Oral gavage; once dose; evenly coated right ear with 25 μL of xylene after 1 h treatment
Result: Significantly relieved mouse ear swelling with a high swelling inhibition rate of 65.32%.
Animal Model: Collagen-induced arthritis (CIA) mice model (DBA/1J mice, male, 6 weeks old)[1]
Dosage: 25, 50, 100 mg/kg
Administration: Intraperitoneal injection; once daily; 19 days, began on day 56 after collagen induced
Result: Decreased the expression of inflammatory cytokines IL-18 and IL-33.
Reduced inflammation and cartilage and bone erosions symptoms.
Animal Model: Adjuvant arthritis (AA) rat model (Sprague-Dawley rats, male, 180 ± 20 g)[1]
Dosage: 30, 60, 120 mg/kg
Administration: Intraperitoneal injection; once daily; 15 days, began on day 21 after chondrex induced
Result: Significantly reduced IL-6 and TNF-α levels.
Decreased synovial hyperplasia accompanied by inflammatory cell infiltration, pannus formation, and bone erosion of cartilage in a dose-dependent manner.
分子量

541.36

Formula

C21H21BrN10O3
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 140 mg/mL (258.61 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8472 mL 9.2360 mL 18.4720 mL
5 mM 0.3694 mL 1.8472 mL 3.6944 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

IDO2-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8472 mL 9.2360 mL 18.4720 mL 46.1800 mL
5 mM 0.3694 mL 1.8472 mL 3.6944 mL 9.2360 mL
10 mM 0.1847 mL 0.9236 mL 1.8472 mL 4.6180 mL
15 mM 0.1231 mL 0.6157 mL 1.2315 mL 3.0787 mL
20 mM 0.0924 mL 0.4618 mL 0.9236 mL 2.3090 mL
25 mM 0.0739 mL 0.3694 mL 0.7389 mL 1.8472 mL
30 mM 0.0616 mL 0.3079 mL 0.6157 mL 1.5393 mL
40 mM 0.0462 mL 0.2309 mL 0.4618 mL 1.1545 mL
50 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9236 mL
60 mM 0.0308 mL 0.1539 mL 0.3079 mL 0.7697 mL
80 mM 0.0231 mL 0.1154 mL 0.2309 mL 0.5772 mL
100 mM 0.0185 mL 0.0924 mL 0.1847 mL 0.4618 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO2-IN-12803768-09-2Indoleamine 2,3-Dioxygenase (IDO)immunotherapeutic avenuesrheumatoid arthritisindoleamine 2,3-dioxygenase 2autoimmune diseasesimmunomodulatory enzymeinflammatory autoimmunitycollagen-induced arthritis mice modeladjuvant arthritis rat modelpathogenic mediatorcancer immunologyneurodegenerative diseasesand neurologicalInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
IDO2-IN-1
目录号：
HY-151093
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z