1. Cell Cycle/DNA Damage Apoptosis
  2. DNA Alkylator/Crosslinker Apoptosis
  3. Illudin M

Illudin M 是一种细胞毒性真菌倍半萜,可以从 Omphalotus illudens 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。

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Illudin M Chemical Structure

Illudin M Chemical Structure

CAS No. : 1146-04-9

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities[1][2].

体外研究
(In Vitro)

Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs)
Concentration: 0.01 μM, 1 μM, 10 μM
Incubation Time: 24 hours, 48 hours,72 hours, 96 hours, 120 hours
Result: Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).
分子量

248.32

Formula

C15H20O3

CAS 号
结构分类
初始来源

Omphalotus illudens

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Illudin M
目录号:
HY-122493
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