Indomethacin  (Synonyms: Indometacin)

Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research^[1][2][3].

Indomethacin (Indometacin)（0-150 μM；24 小时；3LL-D122 细胞）具有体外抗癌活性^[2]。
Indomethacin (Indometacin) (0-1000 μM) 通过激活 PKR，导致 eF2α 磷酸化，进而关闭病毒蛋白翻译并抑制病毒复制，保护宿主细胞免受病毒损害 (IC₅₀=2 μM)^[3]。
Indomethacin (8 μM, 26 h) 诱导 M1 型的 RAW 264.7 细胞向 M2 型分化^[4]。
Indomethacin (200 μM, 5 天) 诱导人脂肪源性干细胞向神经源样细胞转分化^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indomethacin 可用于动物建模，构建胃肠溃疡模型。

Indomethacin（0.01-10 mg/kg；口服；持续 3 小时；雄性 Sprague-Dawley 大鼠）诱导爪水肿和痛觉过敏 剂量依赖性逆转角叉菜胶引起的痛觉过敏^[1]。
Indomethacin (Indometacin)（10 mg/mL；口服；每天一次，持续 29 天；雄性 C57BL/6J 小鼠）可抑制体内肿瘤生长^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

357.79

C₁₉H₁₆ClNO₄

53-86-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Riendeau D, et, al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.  [Content Brief]

  [2]. Eli Y, et, al. Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. Biochem Pharmacol. 2001 Mar 1;61(5):565-71.  [Content Brief]

  [3]. Amici C, et, al. Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR. Cell Microbiol. 2015 Sep;17(9):1391-404.  [Content Brief]

  [4]. Luo X, Xiong H, Jiang Y, et al. Macrophage Reprogramming via Targeted ROS Scavenging and COX-2 Downregulation for Alleviating Inflammation. Bioconjug Chem. 2023;34(7):1316-1326.

  [5]. Kompisch KM, Lange C, Steinemann D, et al. Neurogenic transdifferentiation of human adipose-derived stem cells? A critical protocol reevaluation with special emphasis on cell proliferation and cell cycle alterations. Histochem Cell Biol. 2010;134(5):453-468.  [Content Brief]