1. Immunology/Inflammation
    Autophagy
  2. COX
    Autophagy
  3. Indomethacin sodium hydrate

Indomethacin sodium hydrate (Synonyms: Indometacin sodium hydrate)

目录号: HY-14397A 纯度: >95.0%
产品使用指南

Indomethacin sodium hydrate (Indometacin sodium hydrate) 是一种有效的,可透过血脑屏障的,非选择性的 COX1COX2 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50 值分别为 18 nM 和 26 nM。Indomethacin sodium hydrate 通过干扰溶酶体的正常功能来破坏自噬流 (autophagic flux)。

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Indomethacin sodium hydrate Chemical Structure

Indomethacin sodium hydrate Chemical Structure

CAS No. : 74252-25-8

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥550 In-stock
500 mg ¥350 In-stock
1 g ¥450 In-stock
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10 g   Get quote  

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Description

Indomethacin sodium hydrate (Indometacin sodium hydrate) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin sodium hydrate disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

In Vitro

Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin inhibits lipopolysaccharide (LPS)-induced PGE2 production (COX-2) in a human whole blood assay with a potency (IC50=0.68±0.17 μM), and suppresses coagulation-induced TXB2 production (COX-1) (IC50=0.19±0.02 μM). Indomethacin blocks COX-1 with an IC50 of 20±1 nM in U937 cell microsomes at a low arachidonic acid concentration (0.1 μM)[1].

In Vivo

Indomethacin dose-dependently inhibits both the carrageenan-induced rat paw oedema (ED50, 2.0 mg/kg), hyperalgesia (ED50, 1.5 mg/kg), and is also effective at reversing LPS-induced pyrexia in rats (ED50, 1.1 mg/kg)[1]. Indomethacin (2.5 mg/kg, i.p) decreases the number of NeuN+ cells in the animals at 8 days after ET-1 injection. Indomethacin also reduces microglia/macrophage activation at 14 days. Indomethacin significantly increases the number of SVZ DCX+ cells/field at 14 days post stroke[3]. Indomethacin (22.9 mg/kg, p.o.) produces 8 to 10 linear mucosal lesions extended from the fundic to pyloric area of stomach wall[4].

Molecular Weight

433.82

Formula

C₁₉H₂₁ClNNaO₇

CAS No.

74252-25-8

中文名称

吲哚美辛钠盐三水合物

SMILES

O=C(O[Na])CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3.O.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (76.83 mM; Need ultrasonic)

DMSO : 5 mg/mL (11.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3051 mL 11.5255 mL 23.0510 mL
5 mM 0.4610 mL 2.3051 mL 4.6102 mL
10 mM 0.2305 mL 1.1526 mL 2.3051 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
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Keywords:

Indomethacin sodiumIndometacin sodiumCOXAutophagyCyclooxygenaseCOX1COX2autophagicfluxlysosomeNon-steroidalanti-inflammatoryNSAIDInhibitorinhibitorinhibit

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Indomethacin sodium hydrate
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