2. GPCR/G Protein Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease PI3K/Akt/mTOR MAPK/ERK Pathway
  3. G Protein-coupled Receptor Kinase (GRK) Apoptosis Reactive Oxygen Species (ROS) Akt p38 MAPK
  4. IS20

IS20 是一种促动力蛋白受体 1 (PKR1) 激动剂。IS20 通过激活 Akt 或 MAPK 通路，减少 Doxorubicin (HY-15142A) 介导的细胞凋亡 (apoptosis) 和 产生。IS20 可保护小鼠模型的心脏免受 Doxorubicin 诱导的心血管毒性影响，并改善存活率和心脏功能。IS20 不会改变急性 Doxorubicin 治疗对乳腺癌细胞和 MDA-MB-231 异种移植小鼠模型的细胞毒性和抗肿瘤活性。IS20 可用于癌症研究。

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IS20

IS20 Chemical Structure

CAS No. : 324561-95-7

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规格 是否有货
50 mg   询价  
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250 mg   询价  

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Customer Review

IS20 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IS20 is a Prokineticin receptor 1 (PKR1) agonist. IS20 diminishes Doxorubicin (HY-15142A) mediated apoptosis and production by activating Akt or MAPK pathways. IS20 protects the heart against Doxorubicin-induced cardiovascular toxicity and improves the survival rate and cardiac function in mouse models. IS20 does not alter the cytotoxicity and antitumor activity of acute DOX treatment in breast cancer cells and MDA-MB-231 xenograft mouse models. IS20 can be used for cancers research[1].

分子量

387.43

Formula

C23H21N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IS20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IS20324561-95-7IS 20IS-20G Protein-coupled Receptor Kinase (GRK)ApoptosisReactive Oxygen Species (ROS)Aktp38 MAPKPKBProtein kinase BProkineticin receptor 1PKR1DoxorubicinCardiovascular toxicityAnticancerH9c2 cardiomyocytesEDPCsMDA-MB-231 xenograft modelInhibitorinhibitorinhibit

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