1. Apoptosis Metabolic Enzyme/Protease
  2. Glutathione Peroxidase Ferroptosis
  3. JKE-1716

JKE-1716 是一种强效选择性含硝酸 GPX4 抑制剂。JKE-1716 可以通过共价 GPX4 抑制选择性诱导 ferroptosis

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JKE-1716 Chemical Structure

JKE-1716 Chemical Structure

CAS No. : 2421118-05-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1].

IC50 & Target

GPX4[1]; Ferroptosis[1]

体外研究
(In Vitro)

JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability[1].
JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: LOX-IMVI cells
Concentration: 0~100 nΜ
Incubation Time: 72 hours
Result: Inhibited cell viability.
分子量

451.30

Formula

C20H20Cl2N4O4

CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

参考文献
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This equation is commonly abbreviated as: C1V1 = C2V2

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
JKE-1716
目录号:
HY-139001
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