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KRM-III 

目录号: HY-136427
产品使用指南

KRM-III 是一种有效的具有口服活性的 T 细胞抗原受体 (TCR) 抑制剂。KRM-III 抑制 TCR 和肉豆蔻酸乙酸酯/佛波霉素/离子霉素诱导的 NFAT 核因子活化和 T 细胞增殖,IC50 约为 5 μM。抗炎活性。

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KRM-III Chemical Structure

KRM-III Chemical Structure

CAS No. : 79220-94-3

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Description

KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1].

Molecular Weight

252.33

Formula

C₁₅H₁₂N₂S

CAS No.

79220-94-3

SMILES

S=C1NC(C2=CC=CC=C2)=CN1C3=CC=CC=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

KRM-IIIOthersT-cellsTCRantigenNFATanti-proliferationinflammatoryautoimmuneInhibitorinhibitorinhibit

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产品名称:
KRM-III
目录号:
HY-136427
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