1. Peptides
  2. LCKLSL

LCKLSL 是一种 N 末端六肽,是一种竞争性的膜联蛋白 A2 (AnxA2) 抑制剂,可有效抑制组织纤溶酶原激活物 (tPA) 与 AnxA2 的结合。LCKLSL 还可抑制纤溶酶的产生,并具有抗血管生成的作用。

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Custom Peptide Synthesis

LCKLSL Chemical Structure

LCKLSL Chemical Structure

CAS No. : 533902-29-3

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LCKLSL 的其他形式现货产品:

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Top Publications Citing Use of Products

    LCKLSL purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 Mar;159:114173.  [Abstract]

    LCKLSL (5 μM) intervention significantly inhibits ANXA2 protein expression levels when compare to the alcohol group, in activated HSC-T6 cells.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1].

    IC50 & Target

    Annexin A2 (AnxA2)[1]

    体外研究
    (In Vitro)

    In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    675.88

    Formula

    C30H57N7O8S

    CAS 号
    Sequence

    Leu-Cys-Lys-Leu-Ser-Leu

    Sequence Shortening

    LCKLSL

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    LCKLSL
    目录号:
    HY-P2333
    需求量: