1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 信号通路化合物库系列
  5. 凝血-抗凝血化合物库
凝血-抗凝血化合物库 - Coagulation and Anti-coagulation Compound Library

Cat. No.: HY-L136

凝血,也称为血液凝固,是血液从液体状态变为固体凝胶并形成血块的过程。在血管损伤部位精确而平衡地生成的凝血酶,是凝血系统的关键效应酶,参与许多重要生物学过程,如血小板活化、纤维蛋白原转化为纤维蛋白网络、凝血反馈放大等。同时,为了避免机体意外形成血栓,还存在抑制血液凝固的抗凝机制。

正常的凝血机制是一种损伤部位促凝血通路和损伤部位以外抗凝血机制之间的平衡。凝血系统在围手术期或危重症期间可能发生失衡,进而导致血栓形成或出血过多。因此,凝血平衡的生理研究是临床诊断和处理凝血异常的重要基础。

MCE可以提供967种靶向凝血和抗凝血关键靶点的化合物,是凝血-抗凝血机制研究的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 凝血-抗凝血化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,947 个产品以 10 mM 浓度提供,14 个产品以 2 mM 浓度提供,6 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•    A unique collection of 967 Coagulation and Anti-coagulation related compounds for high throughput screening (HTS) and high content screening (HCS).

•    A useful tool to screen new inhibitors of coagulation and anti-coagulation.

•   Target diverse, medicinally active and cell permeable.

•   Bioactivity and safety confirmed by preclinical research and clinical trials.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

产品详情

Product Details

Formulation:

A collection of 967 Coagulation and Anti-coagulation related compounds supplied as pre-dissolved Solutions or Solid
Solution: 947 compounds supplied in 10 mM solution, 14 compounds supplied in 2 mM solution, 6 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

PKC (80)

PAI-1 (16)

MMP (14)

ROCK (10)

Akt (8)

PKA (7)

COX (6)

ERK (5)

AMPK (4)

JAK (4)

Syk (4)

CaMK (3)

CDK (3)

EGFR (3)

HIV (3)

HSV (3)

PI3K (3)

STAT (3)

DYRK (2)

FGFR (2)

HSP (2)

JNK (2)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Coagulation and Anti-coagulation Compound Library
    目录号:
    HY-L136
    需求量: