1. Membrane Transporter/Ion Channel Anti-infection
  2. CRM1 HIV Antibiotic
  3. Leptomycin A

Leptomycin A  (Synonyms: 来普霉素A)

目录号: HY-N6795 纯度: ≥99.0%
COA 产品使用指南

Leptomycin A 是链霉菌的代谢物,是 CRM1 的抑制剂,阻断CRM1和核出口信号相互作用,阻止多种蛋白质的核出口。Leptomycin A 抑制 HIV-1的复制。活性略低于 Leptomycin B。

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Leptomycin A Chemical Structure

Leptomycin A Chemical Structure

CAS No. : 87081-36-5

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1 mg ¥4800
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B[1][2].

IC50 & Target

HIV-1

 

分子量

526.70

Formula

C32H46O6

CAS 号
性状

固体

颜色

Colorless to light yellow

中文名称

来普霉素A

结构分类
初始来源

Streptomyces

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HY-N6795
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