1. Metabolic Enzyme/Protease
    Anti-infection
  2. Ser/Thr Protease
    Virus Protease
    Cathepsin
  3. Leupeptin

Leupeptin 

目录号: HY-18234
产品使用指南

Leupeptin 是一种广谱的、具有细胞膜渗透性的蛋白酶抑制剂。 Leupeptin 能有效抑制丝氨酸、半胱氨酸和苏氨酸蛋白酶。 Leupeptin 能抑制 Mpro (SARS-CoV-2 的主要蛋白酶),还具有抗炎活性。

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Custom Peptide Synthesis

Leupeptin Chemical Structure

Leupeptin Chemical Structure

CAS No. : 55123-66-5

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Leupeptin 的其他形式现货产品:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].

IC50 & Target

Cathepsin B, Cathepsin H, Cathepsin L, Ser/Thr Protease, Mpro[1][2][3].

体外研究
(In Vitro)

Leupeptin (0.06-200 µM; 72 h) 显著抑制 Vero 细胞中 SARS-CoV-2 病毒 RNA (vRNA) 的拷贝数[1]
。 Leupeptin 抑制 Vero 细胞中 SARS-CoV-2 的 RNA 水平,EC50 值为 42.34 µM[1]
。 Leupeptin 对 Mpro 有一定的抑制活性,其 IC50 值为127.2 µM[1]
。 Leupeptin 对人类冠状病毒 229E 株的 IC50 值为 0.4 µg/mL (约 1 µM)[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Vero cells
Concentration: 0.06-200 µM
Incubation Time: 72 h
Result: Significantly decreased copy numbers of SARS-CoV-2 viral RNA (vRNA).
体内研究
(In Vivo)

Leupeptin (0, 9, 18, 36 mg/kg; i.p.; single) 具有很好的动物耐受性,并在总组织提取物、溶酶体以及富含自噬体的颗粒部分以剂量依赖的方式显著诱导 LC3b-II 的增加[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6NCrl male mice (6-8 weeks old, 20-25 g)[1].
Dosage: 0, 9, 18, 36 mg/kg
Administration: Intraperitoneal injection; single
Result: Promoted the accumulation of LC3b-II in mouse liver.
分子量

426.55

Formula

C20H38N6O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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Leupeptin
目录号:
HY-18234
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