1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. Leupeptin hemisulfate

Leupeptin hemisulfate 

目录号: HY-18234A 纯度: 98.00%
产品使用指南

Leupeptin hemisulfate 是一种可透过膜的巯基蛋白酶抑制剂,可抑制 Cathepsin B, Cathepsin HCathepsin L,并损害两性溶酶体的融合。Leupeptin hemisulfate 也具有抗炎作用。

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Leupeptin hemisulfate Chemical Structure

Leupeptin hemisulfate Chemical Structure

CAS No. : 103476-89-7

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in Water ¥550 In-stock
5 mg ¥500 In-stock
10 mg ¥700 In-stock
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Description

Leupeptin hemisulfate is a membrane-permeable thiolprotease inhibitor that inhibits Cathepsin B, Cathepsin H and Cathepsin L, and also impairs amphisome-lysosome fusion[1]. Leupeptin hemisulfate also exhibits anti-inflammatory effect[2].

IC50 & Target

Cathepsin[1]

In Vivo

Leupeptin (0-36 mg/kg; intraperitoneal injection; for 4 hours; C57BL/6NCrl male mice) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction[2].

Animal Model: C57BL/6NCrl male mice (6-8 weeks old, 20-25 g)[2]
Dosage: 0 mg/kg, 9 mg/kg, 18 mg/kg, 36 mg/kg
Administration: Intraperitoneal injection; for 4 hours
Result: Promoted the accumulation of LC3b-II in mouse liver.
Molecular Weight

475.59

Formula

C₂₀H₃₈N₆O₄ . ₁/₂H₂SO₄

CAS No.

103476-89-7

Sequence

Ac-Leu-Leu-Arg-CHO

Sequence Shortening

Ac-LLR-CHO

SMILES

O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N.[0.5H2SO4]

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 19 mg/mL (39.95 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1027 mL 10.5133 mL 21.0265 mL
5 mM 0.4205 mL 2.1027 mL 4.2053 mL
10 mM 0.2103 mL 1.0513 mL 2.1027 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
References

Purity: 98.00%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Leupeptin hemisulfate
目录号:
HY-18234A
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