2. Inhibitory Antibodies
  3. Lorukafusp alfa

Lorukafusp alfa  (Synonyms: 14.18 mAb; hu14.18-IL2; EMD 273063)

目录号: HY-P990076

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Lorukafusp alfa (14.18 mAb; hu14.18-IL2) 是一种免疫细胞因子，由与 IL210 连接的人源化 14.18 抗 GD2 抗体组成。Lorukafusp alfa 具有通过 hu14.18-IL2 与肿瘤细胞表面 GD2 结合激活抗体依赖性细胞毒性 (ADCC) 和补体依赖性细胞毒性介导的活性，随后与效应细胞上的 Fc 受体结合并通过 IL2 受体结合激活 NK 和 T 细胞。Lorukafusp alfa 具有抗肿瘤活性。

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Lorukafusp alfa Chemical Structure

Lorukafusp alfa Chemical Structure

CAS No. : 2131168-99-3

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Lorukafusp alfa 相关抗体

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生物活性

Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity[1].

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纯度 & 产品资料
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Keywords:

Lorukafusp alfa2131168-99-314.18 mAb hu14.18-IL2 EMD 273063EMD273063EMD 273063EMD-273063Others14.18GD2IL210ADCCcomplement-dependent cytotoxicityhu14.18-IL2FcNKT cellsIL2 anti-tumorInhibitorinhibitorinhibit

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