2. Others Protein Tyrosine Kinase/RTK Apoptosis
  3. Reference Standards c-Kit PDGFR Src FGFR Apoptosis
  4. Masitinib mesylate (Standard)

Masitinib mesylate (Standard)  (Synonyms: 甲磺酸马赛替尼 (Standard); AB-1010 mesylate (Standard))

目录号: HY-10209AR 纯度: ≥98%
产品使用指南 技术支持

Masitinib (mesylate) (Standard)是 Masitinib (mesylate) 的分析标准品。本产品用于研究及分析应用。Masitinib mesylate (AB-1010 mesylate) 是一种有效的，生物口服可利用的，且选择性的 c-Kit 抑制剂 (对于人重组 c-Kit，IC50 =200 nM)，它还抑制 PDGFRα/β (IC50s=540/800 nM)，Lyn (对 LynB 的 IC50=510 nM)，Lck，较小程度上抑制 FGFR3 和 FAK。Masitinib mesylate (AB-1010 mesylate) 有抗增殖，促凋亡活性，且毒性低。

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Masitinib mesylate (Standard) Chemical Structure

Masitinib mesylate (Standard) Chemical Structure

CAS No. : 1048007-93-7

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生物活性

Masitinib (mesylate) (Standard) is the analytical standard of Masitinib (mesylate). This product is intended for research and analytical applications. Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity.

分子量

594.75

同用名

甲磺酸马赛替尼 (Standard); AB-1010 mesylate (Standard)

Formula

C29H34N6O4S2
CAS 号
中文名称

甲磺酸马赛替尼 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Masitinib mesylate (Standard) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Masitinib mesylate (Standard)1048007-93-7AB-1010 mesylate (Standard)甲磺酸马赛替尼 (Standard)Reference Standardsc-KitPDGFRSrcFGFRApoptosisSCFRCD117Platelet-derived growth factor receptorFibroblast growth factor receptorInhibitorinhibitorinhibit

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