2. Academic Validation
  3. Effect of several sesquiterpene lactones on lipid peroxidation and glutathione level

Effect of several sesquiterpene lactones on lipid peroxidation and glutathione level

  • Planta Med. 1999 May;65(4):320-4. doi: 10.1055/s-1999-13994.
J Jodynis-Liebert 1,  M Murias,  E Błoszyk
Affiliations

Affiliation

  • 1 Department of Toxicology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland. liebert@usoms.poznan.pl
PMID: 10364836 DOI: 10.1055/s-1999-13994
Abstract

Seven sesquiterpene lactones isolated from Helenium aromaticum: helenalin, mexicanin I, linifolin A, geigerinin, and from Telekia speciosa: 6 alpha-hydroxy-2,3-dihydroaromaticin, asperilin, telekin have been tested for their hydroxyl radical scavenging activity and effect on lipid peroxidation. All compounds were found to be potent hydroxyl radical scavengers but did not affect lipid peroxidation in vitro. In vivo they exerted pro-oxidative properties and caused glutathione level depletion and elevation in Glutathione Peroxidase activity.

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