2. Academic Validation
  3. Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides

Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides

  • Bioorg Med Chem Lett. 2000 Sep 18;10(18):2145-8. doi: 10.1016/s0960-894x(00)00418-2.
M Z Luo 1,  M C Liu,  D E Mozdziesz,  T S Lin,  G E Dutschman,  E A Gullen,  Y C Cheng,  A C Sartorelli
Affiliations

Affiliation

  • 1 Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520-8066, USA.
PMID: 10999490 DOI: 10.1016/s0960-894x(00)00418-2
Abstract

Novel L- and D-configuration dioxolane 5-azacytosine and 6-azathymine nucleosides have been synthesized and evaluated for biological activity. (-)-(2S,4S)-1-[2-(Hydroxymethyl)-1,3-dioxolan-4-yl]-5-azacytosine (6) showed significant activity against HBV, whereas the D-configuration analogue (14) has been found to exhibit potent anti-HIV activity.

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