2. Academic Validation
  3. 3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents

3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents

  • Bioorg Med Chem Lett. 2001 Jan 22;11(2):183-5. doi: 10.1016/s0960-894x(00)00635-1.
Y Kashiwada 1,  J Chiyo,  Y Ikeshiro,  T Nagao,  H Okabe,  L M Cosentino,  K Fowke,  K H Lee
Affiliations

Affiliation

  • 1 Niigata College of Pharmacy, Japan. kasiwada@niigata-pharm.ac.jp
PMID: 11206454 DOI: 10.1016/s0960-894x(00)00635-1
Abstract

Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3',3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethvlsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC5, value of 0.00087 microM and a TI value of 42,400.

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