2. Academic Validation
  3. New chromanone acids with antibacterial activity from Calophyllum brasiliense

New chromanone acids with antibacterial activity from Calophyllum brasiliense

  • J Nat Prod. 2004 Apr;67(4):537-41. doi: 10.1021/np030438n.
Filippo Cottiglia 1,  Boopathy Dhanapal,  Otto Sticher,  Jörg Heilmann
Affiliations

Affiliation

  • 1 Dipartimento Farmaco Chimico Tecnologico, Facoltà di Farmacia, University of Cagliari, 09124 Cagliari, Italy.
PMID: 15104480 DOI: 10.1021/np030438n
Abstract

Six novel chromanone acids (1-6) were isolated from the bark of Calophyllum brasiliense Cambess. Their structures were elucidated on the basis of 1D and 2D NMR experiments, as well as mass spectrometry. All compounds showed moderate to strong Antibacterial activity against Bacillus cereus and Staphylococcus epidermidis, with 1 and 2 being most active. None of the compounds were cytotoxic against KB, Jurkat T, and myosarcoma Cancer cells up to 20 microg/mL.

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