2. Academic Validation
  3. Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity

Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity

  • Bioorg Med Chem Lett. 2004 May 17;14(10):2397-9. doi: 10.1016/j.bmcl.2004.03.029.
Annette Angell 1,  Christopher McGuigan,  Luis Garcia Sevillano,  Robert Snoeck,  Graciela Andrei,  Erik De Clercq,  Jan Balzarini
Affiliations

Affiliation

  • 1 Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.
PMID: 15109620 DOI: 10.1016/j.bmcl.2004.03.029
Abstract

Thieno analogues of the potent and selective furo-pyrimidine anti-VZV nucleoside family bearing a p-alkylphenyl side chain have been synthesised and tested for their Antiviral activity against Varicella-Zoster virus (VZV). While the alkyl chain analogues were shown to retain full Antiviral activity against VZV, these new analogues did not when compared to their furo parent nucleosides.

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