2. Academic Validation
  3. 3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine

3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine

  • J Med Chem. 1992 Sep 4;35(18):3369-72. doi: 10.1021/jm00096a011.
D E Bergstrom 1,  A W Mott,  E De Clercq,  J Balzarini,  D J Swartling
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, Indiana 47907.
PMID: 1527788 DOI: 10.1021/jm00096a011
Abstract

3',3'-Difluoro-3'-deoxythymidine (3) has been synthesized in four steps from thymidine, and characterized by 1H NMR and NOE experiments. The JHF coupling constants support a conformation in solution that is predominantly 2'-endo (S). Although conformationally and sterically nucleoside 3 may resemble Other thymidine analogs which are active against HIV-1, 3 is virtually inactive.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z