2. Academic Validation
  3. Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

  • Bioorg Med Chem Lett. 2004 Dec 20;14(24):5971-4. doi: 10.1016/j.bmcl.2004.10.006.
Clara Cena 1,  Donatella Boschi,  Gian Cesare Tron,  Kostantin Chegaev,  Loretta Lazzarato,  Antonella Di Stilo,  Manuela Aragno,  Roberta Fruttero,  Alberto Gasco
Affiliations

Affiliation

  • 1 Dipartimento di Scienza e Tecnologia del Farmaco, Via P. Giuria 9, I-10125 Torino, Italy.
PMID: 15546710 DOI: 10.1016/j.bmcl.2004.10.006
Abstract

A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate Phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.

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