2. Academic Validation
  3. Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides

Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides

  • J Med Chem. 1992 Feb 7;35(3):533-8. doi: 10.1021/jm00081a015.
J A Secrist 3rd 1,  R M Riggs,  K N Tiwari,  J A Montgomery
Affiliations

Affiliation

  • 1 Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305.
PMID: 1738145 DOI: 10.1021/jm00081a015
Abstract

A series of 2',3'-dideoxy-4'-thionucleoside analogues of purines and pyrimidines, including 4'-thioddI (17), 4'-thioddC (27), and 4'-thioAZT (34), were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV). A stereospecific synthesis of the 2,3-dideoxy-4-thioribofuranosyl carbohydrate precursor 11 starting with L-glutamic acid is described. 2',3'-Dideoxy-4'-thiocytidine (27) displayed significant, but modest activity in vitro against human immunodeficiency virus.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z