2. Academic Validation
  3. The discovery of long acting beta2-adrenoreceptor agonists

The discovery of long acting beta2-adrenoreceptor agonists

  • Bioorg Med Chem Lett. 2007 Jul 15;17(14):4012-5. doi: 10.1016/j.bmcl.2007.04.081.
Alan D Brown 1,  Mark E Bunnage,  Paul A Glossop,  Kim James,  Rhys Jones,  Charlotte A L Lane,  Russell A Lewthwaite,  Simon Mantell,  Christelle Perros-Huguet,  David A Price,  Mike Trevethick,  Rob Webster
Affiliations

Affiliation

  • 1 Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
PMID: 17498952 DOI: 10.1016/j.bmcl.2007.04.081
Abstract

The design and profile of a series of saligenin containing long acting beta(2)-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer durations of action than salmeterol and have the potential for a once daily profile in human.

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