2. Academic Validation
  3. Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity

Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity

  • Bioorg Med Chem. 2007 Dec 15;15(24):7538-44. doi: 10.1016/j.bmc.2007.09.012.
Javier A Ramírez 1,  Andrea C Bruttomesso,  Flavia M Michelini,  Sofía L Acebedo,  Laura E Alché,  Lydia R Galagovsky
Affiliations

Affiliation

  • 1 Departamento de Química Orgánica and UMYMFOR (CONICET-Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA, Buenos Aires, Argentina.
PMID: 17892941 DOI: 10.1016/j.bmc.2007.09.012
Abstract

In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-alpha production by macrophages. A preliminary qualitative structure-activity relationship was established.

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