2. Academic Validation
  3. Design and synthesis of vidarabine prodrugs as antiviral agents

Design and synthesis of vidarabine prodrugs as antiviral agents

  • Bioorg Med Chem Lett. 2009 Feb 1;19(3):792-6. doi: 10.1016/j.bmcl.2008.12.031.
Wei Shen 1,  Jae-Seung Kim,  Phillip E Kish,  Jie Zhang,  Stefanie Mitchell,  Brian G Gentry,  Julie M Breitenbach,  John C Drach,  John Hilfinger
Affiliations

Affiliation

  • 1 TSRL Inc., 540 Avis Drive Suite A, Ann Arbor, MI 48108, USA. wshen@tsrlinc.com
PMID: 19097789 DOI: 10.1016/j.bmcl.2008.12.031
Abstract

5'-O-D- and L-amino acid derivatives and 5'-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was improved compared to the parent drug.

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