2. Academic Validation
  3. HPLC-based activity profiling for GABA(A) receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium

HPLC-based activity profiling for GABA(A) receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium

  • J Nat Prod. 2010 Apr 23;73(4):768-70. doi: 10.1021/np900803w.
Yanfang Li 1,  Inken Plitzko,  Janine Zaugg,  Steffen Hering,  Matthias Hamburger
Affiliations

Affiliation

  • 1 Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
PMID: 20210326 DOI: 10.1021/np900803w
Abstract

A new dihydroisocoumarin was isolated from a dichloromethane extract of Haloxylon scoparium with the aid of a functional assay with Xenopus oocytes transiently expressing GABA(A) receptors of defined subunit composition (alpha(1)beta(2)gamma(2S)). Compound 1 induced a maximum potentiation of the chloride currents by 144.6 +/- 35.3% with an EC(50) of 140.2 +/- 51.2 muM.

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