2. Academic Validation
  3. Synthesis and biological evaluation of 4-(2-(dimethylamino)ethoxy)benzohydrazide derivatives as inhibitors of Entamoeba histolyica

Synthesis and biological evaluation of 4-(2-(dimethylamino)ethoxy)benzohydrazide derivatives as inhibitors of Entamoeba histolyica

  • Eur J Med Chem. 2016 Nov 29:124:445-455. doi: 10.1016/j.ejmech.2016.08.022.
Afreen Inam 1,  Sonam Mittal 2,  Maitreyi S Rajala 2,  Fernando Avecilla 3,  Amir Azam 4
Affiliations

Affiliations

  • 1 Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, 110 025, New Delhi, India.
  • 2 School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
  • 3 Departamento de Química Fundamental, Universidade da Coruña, Campus da Zapateira, 15071 A Coruña, Spain.
  • 4 Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, 110 025, New Delhi, India. Electronic address: amir_sumbul@yahoo.co.in.
PMID: 27598233 DOI: 10.1016/j.ejmech.2016.08.022
Abstract

In the quest for potent antiamoebic agents, a series of hydrazone hybrids (H1H30) have been designed and sequentially synthesized. The dimethylaminoethoxy and hydrazone entities incorporated into one molecule proved to be more persuasive and selective approach towards designing of antiamoebic agent. The synthesized compounds exhibited promising results against E. histolytica. The compound N'-(2-chlorobenzylidene)-4-(2-(dimethylamino) ethoxy)benzohydrazide was most impending among the series. Cytotoxicity profile showed better cell viability on lung Cancer cell line (A549 cells) by MTT assay.

Keywords

Antiamoebic activity; Cytotoxicity; Hydrazones; MTT assay; X-ray crystallography.

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